Baseline energy division increased log energy variance across seven SEEG patients after fixed source correction and pulse order adjustment

We tested whether division by energy before each pulse reduces variation in log response energy. The source was public corrected SEEG data from OpenNeuro ds004696, version 1.0.1. Seven patients supplied 80 groups and 1,665 contact and group pairs. Each group used ten selected good pulses. After linear adjustment for selected pulse order, the geometric variance ratio was 2.18681. All seven patient scores were positive. The conditional 95 percent patient bootstrap interval was 1.67235 to 2.76465. The exact two-sided patient sign-flip probability was 0.015625. This test assumes independent patients and symmetric scores under a zero null. Descriptive time, order, contact, and sequence checks gave ratios above 1. The result measures variation in log total voltage energy after fixed reference and median baseline correction. Higher variation need not mean less physiological information. It does not establish neural error, a brain state, or clinical benefit. The package preserves code, trial values, exact inherited inputs, source versions and hashes, results, checks, and reproduction commands. Fresh header access checks covered all eight source objects. Full source hash evidence is inherited. A fresh full-object rebuild attempt did not complete.

SEEG · intracranial EEG · baseline normalization · voltage energy · variance · pulse order · measurement audit