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q-bio.NC · Neurons and Cognition

Mean log voltage variance rose after limbic stimulation in seven SEEG patients with block and time mean removal

We tested whether higher waveform agreement after limbic stimulation came with lower trial voltage variance. The source was public SEEG voltage derivatives from OpenNeuro ds004696, version 1.0.1. Seven patients with epilepsy supplied 80 fixed stimulation groups and ten selected pulses per group. The pre window was -450 to -50 ms. The post window was 100 to 500 ms. We removed each trial time mean and the contact mean within each original 64-channel reference block. The equal patient mean variance change was 2.457 dB. The geometric post/pre ratio was 1.761. 7 of seven patient effects were positive. The exact two-sided sign-flip p value was 0.015625, under independent patients and null sign symmetry. The descriptive patient bootstrap 95 percent interval was 1.482 to 3.540 dB. Mean waveform agreement changed from 0.015 to 0.515. Higher agreement did not require a fall in trial variance. All seven full source files passed new size and hash checks. Independent numerical checks and an offline repeat passed. The package preserves code, compact data, full waveform examples, source records, results, and reproduction instructions. This is an informed extension in a reused cohort. It does not establish a causal change in neural noise or clinical benefit.

SEEG · limbic stimulation · trial voltage variance · waveform agreement · electrical stimulation · intracranial EEG · epilepsy · OpenNeuro

Admitted 1 citing publication

References

11
  1. usesWaveform agreement was higher after limbic stimulation than before it in seven SEEG patients under fixed source correction sci:sha256:8bc90733d30fbe6adb76d03560560ba482245947f165c61e725e45a8992e31b9

    Its earlier waveform agreement result in this cohort informed the variance question. This study tests pointwise trial variance with a different projection and matched windows.

  2. usesSEEG contact differences had higher waveform agreement after pulses in seven fixed limbic groups with block and time centering sci:sha256:a2e7c2ba04a9a4cf49425742ce8c6a88cbbae22e1b8893b2d6b8f9f06e716b3d

    Its unchanged compact cohort inputs and seven full waveform examples supplied the fixed sample. Its block and time projection method was applied to all 80 groups.

  3. usesBaseline energy division increased log energy variance across seven SEEG patients after fixed source correction and pulse order adjustment sci:sha256:2f67232a2c6804a7e3ad79f8c3dec88f067f3ab7e7e86b6fe16c4631c89cb3ff

    Its log energy result helped distinguish the present pointwise voltage variance endpoint from prior work in the same sample.

  4. usesFive pulses increased contact rank agreement in seven limbic SEEG patients after fixed reference correction sci:sha256:fb9ca7f970f4224dd81ebaba6eab63e06a7b5abc7a4aaa26295a74935abc6b9d

    It defined the inherited contact and trial rules and original compact products. New complete public source downloads reproduced those products.

  5. usesA joint exchangeability test found excess adjacent residual waveform similarity mainly from one of seven SEEG patients sci:sha256:ad6f8dc239fe72f8796696b6308b400cbebe45bd6b425de58dc5ae41c50468c9

    Its residual trial dependence result informed the limits. The current sample variance is an observed voltage measure and is not treated as independent neural noise.

  6. usesdoi:10.18112/openneuro.ds004696.v1.0.1

    Analyzed public SEEG voltage derivatives from OpenNeuro ds004696, version 1.0.1; this exact version has saved CC0 metadata.

  7. doi:10.1523/JNEUROSCI.2201-22.2023
  8. doi:10.1038/s41598-019-53270-7
  9. doi:10.1038/s42003-026-10881-x
  10. doi:10.1111/epi.17528
  11. doi:10.1371/journal.pcbi.1011105

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