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A joint exchangeability test found excess adjacent residual waveform similarity mainly from one of seven SEEG patients

We tested adjacent residual waveform similarity in public OpenNeuro ds004696, version 1.0.1. Seven patients supplied 80 stimulation groups and 1,665 contact-group pairs, with ten good exported pulses per group. After stimulation, mean adjacency excess was 0.02324. The two-sided shared pulse order test gave p = 0.01658. The null requires joint pulse exchangeability within patients and independence between patients. One patient supplied 92.0 percent of the signed effect sum. Without that patient, the mean was 0.00216 and the descriptive order-test p-value was 0.79596. The full-sample 95 percent patient bootstrap interval was [-0.00906, 0.06902]. This result detects an order pattern in the fixed sample under the stated null. It gives weak support for a general patient effect and does not identify a neural mechanism. Source reference and baseline corrections were fixed. The package preserves code, compact data, proof, results, checks, source versions, hashes, and retrieval instructions. A fresh full source rebuild for the largest-effect patient matched all 13 saved arrays exactly.

stereoelectroencephalography · SEEG · pulse order · exchangeability · evoked potentials · waveform similarity · conditional randomization · patient bootstrap · trial dependence

Admitted 2 citing publications

References

4
  1. usesA sign flip test did not detect a larger pulse order ratio after stimulation in seven limbic SEEG patients under independent symmetric null effects sci:sha256:cfe5decab9ef6dedbce2064ab74781918b6bc93c616274990bc447060bc20894

    The earlier study tested the first five pulses against the last five pulses in the same cohort. Its question and result motivated this distinct local order test. This study does not provide an independent patient replication or refute that earlier result.

  2. usesFive pulses increased contact rank agreement in seven limbic SEEG patients after fixed reference correction sci:sha256:fb9ca7f970f4224dd81ebaba6eab63e06a7b5abc7a4aaa26295a74935abc6b9d

    This publication supplied the fixed seven-patient cohort, exact trial Gram matrices, waveform examples, preparation code, and pinned source records. The new study tests adjacent residual similarity. A fresh full sub-01 reconstruction matched all 13 compact arrays.

  3. usesdoi:10.18112/openneuro.ds004696.v1.0.1

    The study analyzes public SEEG derivatives from OpenNeuro ds004696, version 1.0.1.

  4. usesdoi:10.1523/JNEUROSCI.2201-22.2023

    This is the source study for the experiment and trial derivatives analyzed here.

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