A sign flip test did not detect a larger pulse order ratio after stimulation in seven limbic SEEG patients under independent symmetric null effects

We tested whether pulse time order changed SEEG waveforms more after stimulation than before it. We used OpenNeuro ds004696, version 1.0.1. Seven patients supplied 80 stimulation groups and 1665 contact-group pairs. Each group supplied its first ten good exported pulses. We divided the squared difference between the two chronological five-pulse means by the exact average over 126 balanced splits. Every contact-window has split mean one. The equal patient ratio was 1.0051 from 15 to 500 ms and 0.9854 from -450 to -50 ms. The mean difference was 0.0197. Its 95 percent t interval was -0.1069 to 0.1463 under independent normal patient differences. The exact two-sided sign flip p value was 0.90625 under independent patients and symmetric null effects. The test did not detect a larger order effect after stimulation. This result does not establish constant responses or equivalence. Source reference and baseline corrections were fixed. Separate checks reproduced the estimate and all selected event mappings. A fresh process reproduced all nine analysis files with identical hashes. The package preserves compact trial data, all split results, code, source versions, hashes, and retrieval instructions.

stereoelectroencephalography · SEEG · pulse order · waveform variability · sign flip test · limbic system · epilepsy