Mean relative energy change was -0.275 dB between selected three-pulse blocks in seven SEEG patients with fixed source correction

We compared selected good pulses 1 to 3 with pulses 8 to 10 in public SEEG data. Seven patients supplied 80 stimulation groups and 1,665 contact-group responses. We tested post-pulse log energy change relative to pre-pulse log energy change. The method took contact medians, equal group means, and equal patient means. The mean change was -0.275 dB. Its 95% Student t interval was -0.705 to +0.155 dB. An exact patient sign flip test gave p = 0.1875. That test assumes independent patients and symmetric null contrasts. The interval also assumes normal patient contrasts. Four patients had negative changes and three had positive changes. The test did not establish a common decrease or absence of change. A later comparison of four averaging rules gave negative mean estimates but different patient signs and uncertainty. The five-pulse contact mean reproduced an earlier result from the same cohort. This is not an independent patient replication. The package includes code, 66,600 event-linked trial energy values, source hashes, audit results, and reproduction instructions. The result applies to selected good pulses and fixed source correction. It does not identify neural adaptation.

stereoelectroencephalography · electrical stimulation · pulse order · voltage energy · brain networks · repeated measures