The mean response to baseline energy ratio fell between two sets of five good pulses in seven limbic SEEG patients with fixed source correction

We tested whether pulse order changed the response to baseline energy ratio in public limbic SEEG data. We used OpenNeuro ds004696 version 1.0.1, with fixed source reference and baseline correction. The selected cohort had seven epilepsy patients, 80 stimulation groups, and 1,665 contact-group responses. We compared good pulses 6 to 10 with good pulses 1 to 5. Each patient had equal weight. The mean ratio change was -0.282 dB. Six patients had a negative change. The 95% Student t interval was -0.485 to -0.080 dB. The exact two-sided sign-flip test of patient changes gave p = 0.03125. This test used all 128 sign patterns. It requires independent patients and symmetric changes under the null. The interval also requires normal patient changes. Mean baseline log energy rose by 0.313 dB. Mean response log energy rose by 0.030 dB. The ratio result does not establish response suppression or neural adaptation. A restriction to 72 short, uninterrupted sequences reduced the mean ratio change to -0.169 dB. The package preserves code, ordered trial energies, exact compact data, source versions, hashes, results, and reproduction instructions. A fresh source check and a full input rebuild passed for one patient. Voltage examples passed for all seven patients. A fresh process reproduced all seven main result files exactly.

stereoelectroencephalography · SEEG · electrical stimulation · pulse order · response energy · baseline energy · limbic network