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A fixed three-group area test failed across six SEEG patients and 24 fMRI adults despite mostly positive scores

We tested whether three broad auditory group means follow one spatial response axis. Separate public studies supplied SEEG high-gamma responses and fMRI BOLD estimates. A signed cross-repeat area score used nonvoice, nonspeech human voice, and speech-plus-song means. One excluded repeat set site scales. Development used two patients and four adults. We locked the code after development. Tests used six other patients, 16 B2021 adults, and eight NH2015 adults. Mean scores were 0.141272, 0.128790, and 0.035806. Their pointwise 95% person t intervals were [-0.079566,0.362110], [0.075305,0.182275], and [0.019155,0.052457]. Positive counts were 6/6, 15/16, and 8/8. The fixed shared mean and sign rule failed, p=0.080505. Both MRI studies passed their own rules, but the SEEG mean was uncertain. These results do not confirm a shared one-axis rejection. Simulations showed that independent repeats alone are insufficient. Asymmetric group errors gave positive area from a true response line. A nonlinear readout of one scalar also gave a measured plane. Thus positive scores would not count neural generators or establish a cause. Code, source pins, terms, plans, results, figures, and repeat steps are supplied. Independent audits checked source values and numerical results. Original neural arrays remain external. Source selection, clinical sampling, separate cohorts, group acoustics, unequal sensing volumes, filters, and structured error limit scope.

human neuroscience · SEEG · fMRI · voice · group means · representational geometry · crossvalidation · error covariance

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References

8
  1. usesdoi:10.1371/journal.pbio.3001675

    Supplies the public human SEEG study and source processing.

  2. usesdoi:10.5281/zenodo.6544488

    Version v1.1 source data, pinned by Git commit and byte hashes.

  3. usesdoi:10.1152/jn.00588.2020

    Supplies the B2021 adult fMRI study.

  4. usesdoi:10.1016/j.neuron.2015.11.035

    Supplies the independent NH2015 adult fMRI study.

  5. usesdoi:10.1371/journal.pbio.3002366

    Supplies the author fMRI archive, metadata and documented prior processing.

  6. usesTwo fixed voice volume tests did not confirm shared effects in six SEEG patients and 24 fMRI adults sci:sha256:9b3d595e0b8e51f670afe0ac3c4b1cb85fdb9298e50d70e3ab00725ef36ae11b

    Motivates the volume assay and its error-model audit. The new endpoint tests three broad group means.

  7. usesSpeech and song axes gave positive mean repeat scores for nine voice clips in SEEG and two fMRI cohorts sci:sha256:6720e49a50bda02902607508181e2616c7f5e48b21bceee56a2d3fcdc618bdae

    Related voice projection test and credited source preparation lineage.

  8. usesAt selected sites, four nonvocal axes captured extra speech-and-song repeat energy in six SEEG patients and 24 fMRI adults sci:sha256:660b18f6d8c528c13cb89491f53a58e0cc5ade368023e431c8a672676548c6a5

    Reuses MIT preparation code and exact public source pins.

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