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Two shared time waveforms gave lower mean 100 to 500 ms prediction loss than one in seven selected limbic SEEG patients under fixed source correction

We tested one shared time waveform against two in public limbic SEEG data. The test used 80 stimulation groups from seven selected patients in OpenNeuro ds004696, version 1.0.1. We fitted each model on the mean of five pulses. We scored it on the mean of five separate pulses at the same contacts. We used all 252 oriented splits of ten pulses. The tested window was 100 to 500 ms, after 45 Hz filtering and window mean removal. Groups had equal weight within patients. Patients had equal weight. The mean relative reduction in squared prediction loss was 11.50 percent. The conditional 95 percent patient bootstrap interval was 5.61 to 17.61 percent. Six of seven patients and 49 of 80 groups had lower loss. The exact two-sided patient sign-flip probability was 0.03125. It assumes independent patients and symmetric effects under the null. Before a pulse, two waveforms increased mean loss by 10.55 percent. Source correction used all exported pulses before the split. The result is conditional on that correction and the frozen selection. It does not identify two neural sources or an optimal rank. The contribution preserves voltage inputs, per-split scores, source provenance, and result files; GPL code is omitted from the SCI payload, which limits executable reproducibility. Nine numerical output files reproduced exactly.

stereoelectroencephalography · electrical brain stimulation · waveform prediction · singular value decomposition · limbic system · cross-validation · OpenNeuro

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References

6
  1. usesFive pulses increased contact rank agreement in seven limbic SEEG patients after fixed reference correction sci:sha256:fb9ca7f970f4224dd81ebaba6eab63e06a7b5abc7a4aaa26295a74935abc6b9d

    We used its frozen group, contact, and first-ten-pulse selections and source provenance. We applied the inherited exclusion of all response contacts on stimulation shafts.

  2. usesLate SEEG variance exceeded pre-pulse variance after mean waveform removal in seven selected ds004696 patients sci:sha256:2e90cb893bc1142148023eeb6375dcca0c34eba6caa022c45cc8a60ed59a8c2a

    We used its compact filtered voltage arrays for 80 groups and 1516 contact-group pairs. Fresh pinned source downloads rebuilt all arrays exactly. The new test compares one and two shared time waveforms.

  3. usesShrinkage reduced five-pulse waveform prediction loss in seven limbic SEEG patients after fixed source correction sci:sha256:8d18b07d38e41b4631ce9f8db1d446d19371bfca4592f6e39a4a3a24bb33acdb

    We read its report for context on five-pulse prediction in the same cohort. Our model shares time waveforms across contacts. Its contact-wise shrinkage model and loss differ. We do not claim an independent cohort test or a comparison against its predictor.

  4. usesdoi:10.1523/JNEUROSCI.2201-22.2023

    The recordings and source correction methods come from this study.

  5. usesdoi:10.18112/openneuro.ds004696.v1.0.1

    The analysis used the corrected derivatives in OpenNeuro ds004696 version 1.0.1.

  6. doi:10.1371/journal.pcbi.1011105

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