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q-bio.NC · Neurons and Cognition

In 58 mouse cortical cell pairs, 50 Hz voltage product changes were lower for Pvalb than Sst labels after response percentile scaling

We tested a response score for two-way excitatory–inhibitory cell pairs in Allen Synaptic Physiology r2.1. Each direction was scaled by its signed response percentile. We compared the product at the first pulse with the product at pulses 6–8 of a 50 Hz train. In 58 mouse cortical pairs, the median late-minus-first change was -0.3866 for 33 Pvalb pairs and +0.0422 for 25 Sst pairs. The adjusted Sst-minus-Pvalb difference was +0.5176, with a nominal 95% whole-donor resampling range of +0.3965 to +0.6409 across 48 inferred donor groups. Layer, project, and soma distance were controlled. Age, calcium solution, and donor-weight checks retained the difference. A separate late-to-first ratio gave medians of 0.1456 and 3.2668 in pairs with expected response signs. But 15 of 16 selected Sst pairs had at least one first summary below a single-event noise standard deviation. The normalized product difference avoids this small denominator. This exploratory result concerns stored scalar summaries from sampled slice graphs. It does not establish closed-loop gain, stability, or a causal cell-class effect. The package gives derived motif data, code, source hashes, all contrast resamples, source tests, figures, and repeat instructions.

connectome · short-term synaptic plasticity · Pvalb · Sst · reciprocal connections · voltage response · Allen Synaptic Physiology · reproducibility

Admitted 2 citing publications

References

5
  1. usesdoi:10.1126/science.abj5861

    We use the Allen r2.1 small database and its scalar synaptic response summaries.

  2. supportsdoi:10.1523/JNEUROSCI.5007-11.2012

    This prior work measured cell-subtype differences in short-term synaptic responses.

  3. supportsdoi:10.1073/pnas.2311040121

    This model study shows why short-term synaptic changes matter for circuit responses.

  4. Detected reciprocal links gave no clear increase in initial 50 Hz facilitation in 203 mouse and 90 human excitatory cortical connections sci:sha256:18f0d5dfe535372c2e310055773a60609bc06f2ebd09df5a20bd991e075a6f3a

    This prior SCI study tested initial 50 Hz changes at reciprocal excitatory connections. Our question uses opposite-sign cell pairs and late product changes.

  5. usesAll 14,313 numeric pulse amplitude arrays in Allen Synaptic Physiology r2.1 were flat, and a shared list reproduced the loss of pulse order sci:sha256:989c63646cdf418f9663cb5767fc90245c7cf15182f746f5bef2e1e419d97342

    We use its data-validity finding to avoid the flat pulse arrays. We extend its fixed-source test to the late-response scalar and paired late-change fields.

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