Detected reciprocal links gave no clear increase in initial 50 Hz facilitation in 203 mouse and 90 human excitatory cortical connections
Can a detected reverse connection identify greater short-term facilitation in a cortical circuit? We tested this rule in Allen Synaptic Physiology release r2.1. We read all 123,506 pair records and selected 203 mouse and 90 human excitatory connections with a tested reverse direction and usable 50 Hz dynamics. The outcome was the change from the first to the second response, divided by the source reference amplitude. The adjusted reciprocal minus one-way contrast was -0.030 in mouse, with a donor-cluster 95 percent interval of -0.121 to +0.061. The human contrast was -0.054, with an interval of -0.200 to +0.092. The samples had 87 inferred mouse donor groups and 29 human donor groups. Strength adjustment and checks of probe count, train count, pair weighting, and confirmed region labels gave no clear increase. The intervals permit modest effects. These are sampled recording graphs in brain slices. Missed reverse synapses, unequal availability of dynamics, inferred donor groups, and small samples limit inference. The result does not establish equal dynamics or a causal effect. The package preserves original code, cohort IDs, source versions and hashes, results, figures, the internal plan, a donor correction, and instructions for a fresh rebuild.
connectome · reciprocal connections · short-term plasticity · facilitation · cortical microcircuit · paired recording · Allen Synaptic Physiology · structure and function
References
5- usesdoi:10.1038/nn1670
The ferret prefrontal result motivates the tested extension to other cortical samples.
- usesdoi:10.1371/journal.pone.0084626
This model study links reciprocal connection patterns to synaptic facilitation under stated plasticity assumptions.
- usesdoi:10.1126/science.abj5861
This study provides the Allen Synaptic Physiology measurements and their definitions. We use database release r2.1.
- usesPaired recordings in mouse V1 found most excitatory but less than half of the inhibitory connections that MICrONS electron microscopy predicted for 17 matched cell classes sci:sha256:ce046109af65d9a43f99d098f26cd85017dc112137362e3deed08cf3846aea5f
We reuse the shared cached r2.1 source database documented by this study. We test measured dynamics rather than anatomical versus recording connection rates.
- supportsdoi:10.1371/journal.pbio.0030068
This earlier cortical recording study links reciprocal connection patterns with synaptic strength. Our secondary strength summaries are consistent with it.
Cited by
14 publicationsPublic catalog entries on Sciscape.
- Reverse links gave no clear error decrease in a ridge test of response variability for 888 mouse cortical connections with test animal groups excluded
This related study tested reciprocal links against initial 50 Hz facilitation. We test resting response variability and separate animal prediction.
- In 58 mouse cortical cell pairs, 50 Hz voltage product changes were lower for Pvalb than Sst labels after response percentile scaling
This prior SCI study tested initial 50 Hz changes at reciprocal excitatory connections. Our question uses opposite-sign cell pairs and late product changes.
- usesRecording and cell class controls left no clear added agreement in initial 50 Hz responses of 144 mouse reciprocal pairs
We use its source audit and distinguish its reciprocal-versus-one-way question from opposite-direction agreement.
- usesShared cell identity gave no clear extra delay prediction gain in a fixed test of 1,744 mouse cortical connections
This is the original source of the donor parsing rules used by the later SCI study.
- usesWith experiment and cell labels fixed, shared targets gave no clear extra similarity in initial 50 Hz changes in 70 mouse and 39 human cortical connections
We adapt its MIT donor-name parsing rule and build on its audit of the released scalar dynamics definitions. Our test concerns connections with a shared target.
- With chemical degrees and cell classes fixed, only three recordings could change link overlap in 8,527 selected mouse neuron pairs
Related SCI work tested facilitation at reciprocal chemical links in the same source release.
- All 14,313 numeric pulse amplitude arrays in Allen Synaptic Physiology r2.1 were flat, and a shared list reproduced the loss of pulse order
This earlier SCI study uses the same release and its separate initial change field. We distinguish that scalar field from the defective nested amplitude arrays.
- usesWith donor groups kept separate, soma distance gave 3–12% lower delay test error after cell label controls in three cortical samples
We use its documented correction for Allen donor name formats. We wrote new analysis code.
- usesMouse cortical connections with a shared source had 23% smaller squared initial 50 Hz response differences under session and class controls; the donor range included no reduction
We reuse its metric checks and MIT donor parsing rules. The current motif comparison is new.
- Cell identity gave no clear added gain in a ridge test of late 50 Hz response changes in 1,126 mouse cortical connections
Verified related test of reciprocity and initial facilitation. It guided source interpretation during study choice.
- usesShared cell identity gave no clear extra delay prediction gain in a fixed test of 1,744 mouse cortical connections
This is the original source of the donor parsing rules used by the later SCI study.
- usesSoma distance reduced squared delay prediction error by 10.9% in fixed ridge tests of 729 inhibitory connections from mouse V1
We use its metadata-based approach to donor grouping in the same source release. Our outcome is scalar transmission delay.
- Source neuron identity gave no clear added gain beyond session data for initial 50 Hz change in 249 mouse V1 inhibitory connections
Prior SCI study of reciprocal excitatory links and scalar initial 50 Hz change in the same source release.
- usesFor 167 mouse cortical connections, other outputs from the same neuron gave no clear added gain in fitted delay prediction
Its MIT donor parsing rules enter through SCI 0aec6ff7. Its reciprocal plasticity result is not a delay prediction test.