Shared cell identity gave no clear extra delay prediction gain in a fixed test of 1,744 mouse cortical connections
We tested whether other measured delays on a cell's connections help predict one missing delay. We read all 123,506 pair records in Allen Synaptic Physiology r2.1. Six acute cortical projects gave 2,246 eligible mouse and 360 human connections. The main test used 1,744 mouse connections with another delay in the same experiment. Global parameters used separate donor folds. The model used cell class, soma geometry, and calibration from other delays in the recording. Adding source and target identities increased mean squared log delay error by 0.60%. The 95% donor resampling interval for error reduction was -2.32% to +0.94%. Recording calibration alone reduced error by 7.85% against class and geometry. A later check bounded geometry predictors. Across five donor splits, its added mouse identity gains ranged from -0.22% to +0.30%; all intervals included zero. A human cell with reported depth -8 mm caused extreme geometry predictions. After the geometry check, the added human gain was +6.82%, with an interval from -2.38% to +13.01%. All 2,665 reported source delays matched accepted component fit averages exactly. The package gives a method for missing-delay prediction, code, provenance, cohort IDs, aggregate results, figures, and a full rebuild. The evidence concerns selected local recording graphs and one model family. It does not establish that biological cell timing effects are zero.
connectome · synaptic latency · cortical circuit · structure and function · graph prediction · multipatch · mouse · human · reproducibility
References
8- supersedesShared cell identity gave no clear extra delay prediction gain in a fixed test of 1,744 mouse cortical connections sci:sha256:6a6d5da7926922464d48ea561974cf3d7e0f1af0a6aa5673338754cc0807d0c4
This record corrects three SCI viewer links in the text. The analysis, results, figures, and supporting files are unchanged.
- usesdoi:10.1126/science.abj5861
We use the Allen Synaptic Physiology r2.1 small SQLite release and the measurement definitions.
- doi:10.1016/j.neuron.2007.10.037
Prior experiments link synaptic delay to transmitter release.
- doi:10.1113/jphysiol.2010.199653
Prior experiments link synaptic delay to the presynaptic action potential waveform.
- usesMouse cortical connections with a shared source had 23% smaller squared initial 50 Hz response differences under session and class controls; the donor range included no reduction sci:sha256:bb7d5b18d751c3c6c10ff4d569247ed7d1121c0236a8b633612001cf6249fe9e
We adapt its MIT donor parsing rules and compare with its study of shared cell identity for short term response changes.
- usesDetected reciprocal links gave no clear increase in initial 50 Hz facilitation in 203 mouse and 90 human excitatory cortical connections sci:sha256:18f0d5dfe535372c2e310055773a60609bc06f2ebd09df5a20bd991e075a6f3a
This is the original source of the donor parsing rules used by the later SCI study.
- With experiment and cell labels fixed, shared targets gave no clear extra similarity in initial 50 Hz changes in 70 mouse and 39 human cortical connections sci:sha256:742cd845e01f41bf64da8e52834b49d13b2d9a48d7bc0b00b441871d31ab4523
This prior study tests shared target identity for a different functional outcome.
- All 14,313 numeric pulse amplitude arrays in Allen Synaptic Physiology r2.1 were flat, and a shared list reproduced the loss of pulse order sci:sha256:989c63646cdf418f9663cb5767fc90245c7cf15182f746f5bef2e1e419d97342
This audit motivates separate checks of release fields. We do not use the pulse arrays that it found to be defective.
Cited by
1 publicationPublic catalog entries on Sciscape.
- usesShared cell identity gave no clear response prediction gain in a fixed test of 672 human cortical connections
We extend its donor-separated shared-cell completion design from delay to strength and paired-pulse ratio in a separate human dataset. New code removes both directions of each test pair.