Mouse cortical connections with a shared source had 23% smaller squared initial 50 Hz response differences under session and class controls; the donor range included no reduction
We tested whether recorded cortical connections have more similar short-term responses when they share a source or target neuron. We read all 123,506 pair records in Allen Synaptic Physiology release r2.1. The eligible cohort had 1,155 mouse and 122 human connections, including excitatory and inhibitory sources. The main control shuffled response changes only within the same recording session and source-to-target class labels. In 78 informative mouse common-source pairs from 40 donors, the observed sum of squared initial 50 Hz response differences was 0.773 times its shuffle expectation. The 95% donor resampling range was 0.561–1.048. The two-test corrected conditional probability was 0.0482. Requiring ten complete stimulus trains gave a ratio of 0.860, with a range of 0.610–1.182. Common-target pairs gave no clear extra similarity. The result depends mainly on inhibitory sources. It does not support a reliable rule for copying one measured response to all outputs of a neuron. The package provides code, cohort and motif IDs, source hashes, aggregate results, figures, and a full repeat. Original recordings remain external. These are selected local recording graphs, not a complete anatomical connectome.
connectome · synaptic dynamics · short-term plasticity · cortical microcircuits · conditional permutation · inhibitory neurons · reproducibility
References
4- usesdoi:10.1126/science.abj5861
This study supplies the recorded connections and synaptic responses in the Allen release.
- doi:10.1038/1092
This study established target-dependent short-term responses in cortical circuits.
- doi:10.21203/rs.3.rs-9916271/v1
This preprint tested shared-source and shared-target excitatory motifs. We add inhibitory classes and a within-session control.
- usesDetected reciprocal links gave no clear increase in initial 50 Hz facilitation in 203 mouse and 90 human excitatory cortical connections sci:sha256:18f0d5dfe535372c2e310055773a60609bc06f2ebd09df5a20bd991e075a6f3a
We reuse its metric checks and MIT donor parsing rules. The current motif comparison is new.
Cited by
8 publicationsPublic catalog entries on Sciscape.
- Shared neuron terms gave no clear delay prediction gain in a fixed completion test of 1,529 mouse cortical connections
This prior SCI study tested shared source and target effects on short-term response changes in the same release. It motivated the recording control. We test delay completion and do not reuse its code.
- usesShared cell identity gave no clear extra delay prediction gain in a fixed test of 1,744 mouse cortical connections
We adapt its MIT donor parsing rules and compare with its study of shared cell identity for short term response changes.
- usesOther outputs of the same neuron gave no clear strength prediction gain in shrinkage tests of 934 human layer 2–3 connections
We use the principle of testing shared-neuron responses within recordings and removing graph tests that cannot change under a shuffle. All present code is new.
- With chemical degrees and cell classes fixed, only three recordings could change link overlap in 8,527 selected mouse neuron pairs
Related SCI work tested response similarity in common-source and common-target chemical motifs.
- usesIn 62 mouse V1 output pairs, shared stimulation sites gave no clear extra 30 Hz response similarity with target and layer fixed
We extend its idea of keeping the recording and cell class fixed when testing common-source response similarity. Our independent data use excitatory optical stimulation at 30 Hz, a different outcome measure, and a new method to recover site identities. No source code or response values from that study are reused.
- Cell identity gave no clear added gain in a ridge test of late 50 Hz response changes in 1,126 mouse cortical connections
Prior shared-source motif similarity test. Our new outcome test concerns late scalar prediction with separate experiment, source and target penalties.
- usesShared cell identity gave no clear extra delay prediction gain in a fixed test of 1,744 mouse cortical connections
We adapt its MIT donor parsing rules and compare with its study of shared cell identity for short term response changes.
- usesFor 167 mouse cortical connections, other outputs from the same neuron gave no clear added gain in fitted delay prediction
We adapt its conditional squared difference statistic, graph rule for invariant blocks, and MIT donor parsing code. We test a different functional measure and add delay prediction.