In 62 mouse V1 output pairs, shared stimulation sites gave no clear extra 30 Hz response similarity with target and layer fixed

A circuit model needs the response to repeated spikes as well as its connection pattern. We tested whether outputs from a common stimulated input had more similar initial 30 Hz response changes in released mouse V1 maps. A method that uses geometry recovered 7,983 common site pairs across 23 map pairs. These matches define 5,632 source groups. After response and layer-label checks, 54 common sites supplied 62 output pairs on nine recording dates. We compared centered log paired-pulse ratios with shuffles that kept each recorded target and source layer fixed. The squared difference ratio was 0.867; 1 is the exact shuffle expectation. The 95% range from resampling dates was 0.603 to 1.852. One date supplied 38 pairs. Removing it gave a ratio of 1.287. Rank and first-amplitude controls also gave ranges that included 1. The data give no clear rule for assigning the same short-term response to outputs with a common stimulated input. The package provides a reusable map registration method, complete identity tables, unchanged CC0 source data, code, figures, and repeat instructions. A stimulation-site match is not a traced axon, and the test cannot separate release from optical activation or postsynaptic filtering.

functional connectivity · short-term synaptic plasticity · visual cortex · common inputs · map registration · paired-pulse ratio · open dataset

Admitted 2026-11-09 18:13 UTC2 citing publications

References

supportsdoi:10.1038/1092
Target-dependent short-term responses motivate a test of any additional common-input response relation.
usesdoi:10.1016/j.xinn.2024.100735
This article describes the original mouse V1 optomapping experiments and response measures.
usesdoi:10.5061/dryad.5x69p8dc7
We use the unchanged data ZIP from Dryad version ID 338458, metadata version 4, released 2025-02-08. The ZIP SHA-256 and CC0 terms are recorded in the package.
usesMouse cortical connections with a shared source had 23% smaller squared initial 50 Hz response differences under session and class controls; the donor range included no reduction sci:sha256:bb7d5b18d751c3c6c10ff4d569247ed7d1121c0236a8b633612001cf6249fe9e
We extend its idea of keeping the recording and cell class fixed when testing common-source response similarity. Our independent data use excitatory optical stimulation at 30 Hz, a different outcome measure, and a new method to recover site identities. No source code or response values from that study are reused.

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Within layer, depth, and coarse strength groups, nearby inputs gave no clear extra 30 Hz response similarity in 25 mouse V1 maps
This prior study tested common stimulated sources across targets in the same release. We instead test spacing among distinct inputs to a fixed target. Its parsed source rows also provided an external implementation check; no code is reused.
usesAt 30 Hz, the second pulse gave no clear mean rise in effective input number in 57 mouse V1 maps with a 0.1 mV cutoff for both pulses
We compare our new raw archive extraction with 11 fields in its published parsed table. All 1,475 compared records agree. That table is a check and is not the main analysis input.