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q-bio.NC · Neurons and Cognitionq-bio.QM · Quantitative Methods

At 30 Hz, local voltage products fell while total peak products had no clear fall in 60 reciprocal PV–pyramidal pairs from mouse V1

We tested how a second spike changes a response score for two neurons connected in both directions. We used released 30-Hz slice recordings from mouse primary visual cortex. The sample had 60 pairs from 25 mice. Each pair had one pyramidal neuron and one parvalbumin-positive inhibitory neuron. We multiplied the excitatory voltage response by the negative inhibitory voltage response. With a local baseline for each response, the median second-to-first product ratio was 0.487. The equal-mouse mean bounded change was -0.331, with a 95% mouse resampling interval of -0.397 to -0.268. All 25 mouse means were negative. The inhibitory return response accounted for most of the decrease. An added check measured the second peak from the original baseline. That product had no clear decrease: mean bounded change -0.033, with interval -0.110 to +0.041. The paired shift between baseline measures was +0.299, with interval +0.239 to +0.352. Much of the first inhibitory response was still present. Thus, a smaller added response does not establish a smaller total voltage excursion or feedback gain. Odd and even trial scores had modest pair-level agreement, with Spearman correlation 0.315. We reproduced all 628 embedded source waveforms from their first ten accepted trials. The package preserves new code, derived trial and pair data, source hashes, figures, uncertainty draws, and repeat steps. The data describe selected slice connections, not a complete connectome or an active closed loop.

connectome · reciprocal connections · short-term plasticity · parvalbumin · mouse visual cortex · voltage baseline · feedback inhibition · reproducible dataset

Admitted 4 citing publications

References

6
  1. usesdoi:10.1016/j.neuron.2023.12.013

    We use its released recording design, connection labels, source methods, and 30-Hz protocol. We extend its reciprocal strength analysis to a two-pulse voltage product and a baseline comparison.

  2. usesdoi:10.25418/crick.23295188.v1

    Version-specific source of connections.mat, source peak annotations, acceptance flags, and analysis code. The raw member stays external; this package contains derived summaries and independent new code.

  3. In 58 mouse cortical cell pairs, 50 Hz voltage product changes were lower for Pvalb than Sst labels after response percentile scaling sci:sha256:3fa97dffd47cd458239df80c4de897e347a68cb168f64fcb4008b5fb8c276d6d

    Prior pair-level voltage product analysis in Allen Pvalb and Sst recordings at 50 Hz. Our independent V1 recordings use a different pulse comparison and expose baseline dependence.

  4. Recording and cell class controls left no clear added agreement in initial 50 Hz responses of 144 mouse reciprocal pairs sci:sha256:68f047b73392ee440a4b219b558a0865646d318aefb1f1a5714bfcad248cb881

    Related test of agreement between reciprocal short-term response changes in Allen recordings. It motivates keeping direction-specific changes distinct from the joint product change.

  5. The reverse PSP reduced squared log amplitude test error by 29% in 88 mouse V1 cell pairs with each test mouse excluded from fitting sci:sha256:1ad67330c1444edf4f919503f4db4fbeb3e04115ed841af1dbfa6d6ddbecfdf7

    This new SCI work uses the same source V1 recordings and 88 reciprocal pairs to test reverse amplitude prediction. We test a distinct two-pulse product and baseline comparison. The studies share biological data.

  6. Visual similarity after mean time course removal was linked to strength in 52 mouse V1 inhibitory connections; estimates within mice were uncertain sci:sha256:7b4b7a4b81de217610e022e581a83de2f2968e8d39eddef4fd49c2ee87938e55

    This new SCI work uses the same source V1 recordings to separate visual similarity components. Our present analysis tests pulse-dependent reciprocal voltage products. The studies share biological data.

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