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q-bio.NC · Neurons and Cognition

Single-gene losses removed all two-step routes for 6,714 pairs with several relays in a fixed 2024 C. elegans short-range peptide model

We tested whether different relay neurons protect possible peptide routes from gene loss. We used 302 neurons and 92 peptide precursor and receptor pairs from the February 2024 C. elegans map. Expression, biochemical support, and anatomy stayed fixed. Each of 100 genes was removed separately in all neurons. The short-range panel at 500 nM had 43,928 directed pairs with no direct edge and at least two relay neurons. For 6,714 pairs (15.28%), at least one gene loss removed every two-step route. For 3,479 pairs, a loss also removed every longer route. A control that required two different relay role profiles gave 4,980 vulnerable pairs out of 41,857. For 83 pairs, a loss kept first and second legs at different relays but left no complete two-step route. DMSR-7 loss removed all 42 two-step routes from RIS to AS03, while a three-step route remained. Under uniform selection of one gene, the mean two-step failure probability was 0.00318544. Independent edge losses with the same edge survival probabilities gave 0.0000439260. Range, cutoff, and fixed-panel controls changed the counts but retained the gene-sharing result. Independent graph algorithms and a full numerical repeat passed. These are counts of listed support in a fixed model. They do not establish peptide-triggered release, mutant responses, or functional rescue. The package preserves code, input layers, source URLs and hashes, all pair results, figures, and repeat instructions.

C. elegans · neuropeptide · connectome · gene deletion · relay neurons · correlated failure · reachability

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References

6
  1. usesOne gene loss removes all listed support for 5,407 multichannel connections in the 2024 short-range C. elegans peptide model sci:sha256:ca108f7e42c2e47e88eeb5d6ad7b4aaa0d7a256d19e214b2bc1d3ef954ae4367

    We extend its direct-edge question to routes through relay neurons. We use its identified input version and shared source cache. An independent recount reproduces its 5,407 direct-edge cases.

  2. usesdoi:10.1016/j.neuron.2023.09.043

    We analyze the source peptide channel layers, with the February 2024 update at Git commit 6689619236ba1b4681a9a77b3d918d513416336c.

  3. usesdoi:10.1016/j.cell.2021.06.023

    CeNGEN expression data are an input to the source map.

  4. usesdoi:10.1016/j.celrep.2023.113058

    The source map uses these peptide-receptor interaction data.

  5. Predicted self-signaling pair counts fell within matched receptor profile ranges in 127 C. elegans expression groups sci:sha256:70c513a1b25c8f973e923136e6aae7e5ea6deff017b8baaf05011f76e608ea52

    This prior analysis documents shared expression profiles in the peptide map. We derive channel role profiles independently.

  6. Independent connection models overstate two-route reliability in eight C. elegans brains under independent loss of synapse sites sci:sha256:e4e968f83ac4898fed7ad12dae72e6e8007240a0bd95c1d5ea014ad90cd9fd48

    This prior study tests shared synapse-site loss across routes. We test shared gene loss in peptide routes and distinguish two-step loss from all-length disconnection.

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