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q-bio.NC · Neurons and Cognitioneess.SP · Signal Processing

Third moment asymmetry at 31.25 ms gave mean label concordance of 0.576 within name groups in paired interictal 1 to 45 Hz SEEG from 30 selected patients

We tested third moment temporal asymmetry in public SEEG from 30 selected patients. Each patient had two 60 second interictal clips in the 1 to 45 Hz band. The fixed lag was 31.25 ms. Mean clinical seizure onset label concordance within electrode name groups was 0.575649. Mean concordance for 39 fixed spectrum phase controls per pair and run was 0.502935. The mean patient difference was 0.072713, with a descriptive 95% bootstrap interval of -0.004170 to 0.144547. The difference was positive in 21 patients and negative in nine patients. The exact direction P value was 0.042774 under independent patients and equal sign probabilities. This test does not test a population mean. Mean pair rank correlation between runs was 0.359526. Concentration and raw line length gave higher mean correlations of 0.526863 and 0.936217. Clipping large increments reduced mean concordance to 0.535867. These results do not establish a stable clinical marker. All arrays in 60 signal inputs matched a rebuild from pinned public EDF prefixes. All 221 metadata files matched a fresh pinned Git checkout. The package preserves inputs, source code, controls, results, provenance, and reproduction instructions. Unresolved source coordinate units prevent physical pair distance claims.

stereoelectroencephalography · SEEG · temporal asymmetry · third moment · seizure onset · phase controls · signal processing

Admitted 1 citing publication

References

6
  1. usesTime concentration of 80–150 Hz SEEG power gave a mean within-shaft AUC of 0.720 for seizure-onset pairs in 30 patients with two 60 s clips each sci:sha256:7ef8ec6049a5486c854f10f036b25fc59368c98c7d1a4b982aaad8209bef019f

    Used inherited contact quality records, name group selection, and pinned public source manifests for the fixed cohort.

  2. usesLine length normalization reversed the mean seizure onset label rank direction in 1–45 Hz SEEG from 30 patients under a fixed numeric pair rule sci:sha256:de3d594f2ad1497c5930f4b5d24cc31bd1ff298004f108a9c654ede8dcef6dae

    Used all 60 archived 1 to 45 Hz signal clips, the fixed 30 patient cohort, and the source extraction code. Recalculated concentration and line length for comparison.

  3. usesA 15 mm cutoff kept no tested SEEG pairs in 34 patients from ds004100 v1.1.3 when declared meter units were used sci:sha256:e0f25df9a149b5809e2595f144ee9d5480a7234e3f7a2e70d56b14c25f42101e

    Used the coordinate unit audit to limit the inherited pair rule to its numeric values. Made no physical distance claim.

  4. usesReference choice changed relative 30–55 Hz power AUROC by 0.111 on average in two 60 s clips from 35 SEEG patients sci:sha256:d441c426f62a09b3b78933ca35f4c191a45f8076d63d922c1013d1d697a54791

    Used the archived EDF range reader and contact pair code to rebuild the public source signals.

  5. usesdoi:10.18112/openneuro.ds004100.v1.1.3

    This exact version is the public SEEG source used for the signal arrays and clinical labels; the publication records version 1.1.3 and its CC0 license.

  6. doi:10.1016/j.clinph.2016.07.001

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