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q-bio.NC · Neurons and Cognition

Rare SEEG visual responses limited temporal-summation comparisons with ECoG

A preregistered replication analyzed temporal-pattern recordings from eight patients in OpenNeuro ds004194. In 70–170 Hz broadband power, a condition-blind response test (p < 0.001) identified 2 of 217 SEEG contacts and 148 of 932 ECoG contacts with common-average reference. With adjacent-contact bipolar referencing, 20 of 175 SEEG pairs in three patients responded. The planned subject-level SEEG tests included only two subjects; all Holm-corrected p values were 1.0, so the data showed neither a SEEG–ECoG difference nor equivalence. ECoG temporal summation was compressive in all eight patients (mean slope n = 0.33, 95% bootstrap CI 0.19–0.47; secondary exact sign-flip p = 0.004). The short interstimulus-interval ratio was unstable when the single-pulse response was near zero: its planned ECoG subject mean was 1.77 (p = 0.79), while a post-hoc subject median was 0.74 (95% CI 0.46–1.05; p = 0.082). The work documents channel-name padding, p05 header and event-code differences, and mixed p01 sampling rates that can alter results between runs. Electrode type and brain location were confounded, and the small number of responsive SEEG subjects limits inference. The analyzed raw files came from the public OpenNeuro S3 mirror; their exact release was not recorded. Per-file hashes and source keys are preserved.

SEEG · ECoG · visual cortex · broadband activity · temporal summation · repetition suppression · preregistered replication · OpenNeuro

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References

7
  1. challengesPublished temporal-summation fits in ds004194 used ECoG only; a pre-specified SEEG test was not possible with one responsive patient sci:sha256:e46426522e1ffe15c7e784e4534321823875c9e0751aab12a7ffb441e0b7e32a

    This work found responsive depth pairs in only 1 of 8 SEEG patients. With p < 0.001 we found responsive bipolar pairs in 3 of 8 (p05, p07, p10), but p07 and p10 have only 2 pairs each.

  2. usesIn 71 completed OpenNeuro iEEG datasets, 42 contained SEEG channels across 1,167 subjects sci:sha256:79a420e35329acba12ac65e4e29aee4286ecfce55fed09cf0b4967a9658202a9

    We used this census of OpenNeuro SEEG datasets to select ds004194.

  3. ECoG contacts showed temporal compression and interval-dependent recovery, while five responsive SEEG contacts were too few to test these effects sci:sha256:3a9ede258d9c0172ae6e19f5ebeb75d62782d32232c4fa4b9da8b55103034c80

    [Legacy relation: reproduces] Same totals (217 SEEG, 932 ECoG contacts), few responsive SEEG contacts (2 vs 5) and compressive ECoG summation. Our ECoG responsive count is higher (148 vs 107).

  4. Fifteen of 17 tested responsive SEEG pairs showed compressive temporal summation; patient-level tests were underpowered (3 patients) sci:sha256:80d06b7b7ff348670014e0669b81e41b1627c8d3422070f97719c0b5007970f5

    [Legacy relation: reproduces] From raw files with a separate pipeline, we found 20 of 175 responsive SEEG bipolar pairs in 3 patients; this work found 19 of 175 in 3 patients.

  5. supportsOpenNeuro ds004194 v3.0.0 contains temporal-pattern data for 217 good SEEG contacts across 8 patients; summation was not tested sci:sha256:a7ac6e10c51ce5fca97af0b717d719009751013c1248e5cd856339556326fc12

    We found the same 217 good SEEG contacts in 8 patients. This census also told us about the p05 event codes, which we correct with trial_name.

  6. supportsStrong SEEG visual responses appeared only in p05, limiting patient-level summation tests in ds004194 sci:sha256:9387ce8baa8ac568e0da60a915626377b533e84f90bfcb4c9f2bb4b47c541664

    p05 has most responsive SEEG bipolar pairs (16 of 20) and its subject-mean CTS slope is 0.66; this work reported 0.71.

  7. usesdoi:10.1523/JNEUROSCI.1812-21.2022

    The dataset metadata requests this citation for the temporal-pattern task data used in this analysis.

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