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Published temporal-summation fits in ds004194 used ECoG only; a pre-specified SEEG test was not possible with one responsive patient

This analysis asked whether visually responsive SEEG depth bipolar pairs in OpenNeuro ds004194 show compressive temporal summation (CTS) of the 70–170 Hz visual broadband response, and whether the published Groen et al. fits used SEEG. The inspected published fit file contained 98 electrodes, all typed ECOG, and both fit files set elec_exclude_depth = 1; the published CTS fits therefore used ECoG only. A pre-specified rule selected pairs using TWOPULSE trials (t > 3.5 and mean response > 0.2), with a stop rule requiring at least four patients for patient-level H1 and H2 tests. Only sub-p05 of eight SEEG patients had responsive pairs, so H1 and H2 were not testable. In this one patient, own features showed mean b = 0.77 (b < 1 in 7/8 pairs) and mean two-pulse index A = -1.81 (A < 0 in 14/14); archived per-trial responses from an independent pipeline showed mean b = 0.69 (b < 1 in 8/10) and A = -1.42 (A < 0 in 13/13). These descriptive results agree with compressive summation but are not a population result. An exploratory ECoG positive control found b < 1 in six patients with valid b (mean 0.47; exact one-sided sign-flip p = 1/64 = 0.016). Own features covered 26/32 planned runs; the archived source covered all 32. The public S3 source was unversioned, and the exact dataset release is uncertain. The recorded hashes, assumptions, deviations, code, results, and reproduction steps are preserved in the accompanying text and original files.

visual cortex · SEEG · ECoG · temporal summation · broadband response · intracranial EEG · OpenNeuro

Admitted 1 citing publication

References

5
  1. usesIn 71 completed OpenNeuro iEEG datasets, 42 contained SEEG channels across 1,167 subjects sci:sha256:79a420e35329acba12ac65e4e29aee4286ecfce55fed09cf0b4967a9658202a9

    This census identified ds004194 as a public dataset with SEEG channels and a visual task.

  2. challengesIn ds004194, only 2 of 8 SEEG patients had responsive 70–170 Hz depth pairs; summation was compressive in 12 of 14 pairs, but n = 2 precluded subject-level inference sci:sha256:da88a2f7244933bb5fe6859f475a0403158a34db1a89225f2a067d8b5b07ebfc

    71a5e074 states that Groen et al. pooled ECoG and SEEG. The published fit files contain 98 of 98 ECOG electrodes and set elec_exclude_depth = 1. Also, its sub-p10 pair is not selected with a TWOPULSE-only rule.

  3. In ds004194, only 2 of 8 SEEG patients had responsive 70–170 Hz depth pairs; summation was compressive in 12 of 14 pairs, but n = 2 precluded subject-level inference sci:sha256:da88a2f7244933bb5fe6859f475a0403158a34db1a89225f2a067d8b5b07ebfc

    [Legacy relation: reproduces] An independent pipeline gives the same SEEG pair counts per patient, finds visually responsive pairs mainly in sub-p05, and finds compressive summation in these pairs.

  4. usesIn ds004194, only 2 of 8 SEEG patients had responsive 70–170 Hz depth pairs; summation was compressive in 12 of 14 pairs, but n = 2 precluded subject-level inference sci:sha256:da88a2f7244933bb5fe6859f475a0403158a34db1a89225f2a067d8b5b07ebfc

    The archived per-trial SEEG bipolar responses (all 32 runs) are a second data source for the same pre-specified analysis.

  5. doi:10.1523/JNEUROSCI.1812-21.2022

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