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q-bio.NC · Neurons and Cognitionstat.ME · Methodology

Shared sites reduced mean target order error by 12 to 31 percent in eight C. elegans maps under 50 percent independent site loss and a minimum count of five

We tested how shared chemical synapse sites affect target order by synapse count. We used eight C. elegans brain maps from Witvliet et al. The main set had 2,471 unequal target pairs, with at least five sites per connection. Each site had independent loss probability 0.5. All targets at one site shared its loss. The comparison lost each source-to-target record independently. It kept the same retained count distribution for each connection. Error was the probability of a count reversal plus half the tie probability. We calculated exact probability laws and gave each eligible source cell equal weight. Shared sites reduced mean error by 11.8 to 31.2 percent across maps. The two adult maps each had 104 eligible source cells. Their mean errors fell from 21.70 to 18.14 percent and from 21.86 to 18.37 percent, or 16.4 and 16.0 percent relative reductions. With all positive counts included, adult reductions were 5.3 and 6.3 percent. The result remained after we merged records at shared source nodes or removed the RIA neurons. Other checks also gave lower mean error. The sign at 50 percent retention follows from the model; the maps determine its size. Shared sites cancel from pair count differences. Counts n, m and overlap s give the exact pair law, but a weighted connection matrix does not generally give s. The first two maps had only three eligible sources each. No developmental trend or biological loss rate was estimated. The results do not establish physiological strength, shared release or resistance to damage. The package preserves code, source hashes, sufficient counts, all specified results, figures, proofs and repeat steps. Independent matrix and exact rational checks passed. A fresh source rebuild matched eight numerical CSV files.

Caenorhabditis elegans · connectome · polyadic synapse · target order · synapse counts · site loss · count covariance · reproducible research

Admitted 2 citing publications

References

7
  1. usesdoi:10.1038/s41586-021-03778-8

    We use the eight individual chemical synapse site exports and cell metadata.

  2. supportsdoi:10.1093/genetics/iyab072

    This methods paper explains that ordinary graph matrices omit polyadic structure.

  3. doi:10.1371/journal.pcbi.1001066

    This paper treats connectome uncertainty and alternative weights for polyadic synapses.

  4. supportsTarget pair repeat counts exceeded random means with fixed edge and site counts in eight C. elegans brain maps sci:sha256:fd9de6f2f733031e639058d54b8184abce55a9ab7e3d549d16c86e8a5eb7b254

    This study tests repeated target grouping with connection counts and site target counts fixed.

  5. supportsShared synapse sites increased target count variance in eight C. elegans maps under an independent site loss model with probability 0.5 sci:sha256:399bdcad1d87baa2a47b9dd65985f85e0e1649a4a98020a858f7efea7cba46ee

    This study gives a distinct target-availability covariance result under site loss. We test count differences and target order.

  6. supportsIndependent connection models overstate two-route reliability in eight C. elegans brains under independent loss of synapse sites sci:sha256:e4e968f83ac4898fed7ad12dae72e6e8007240a0bd95c1d5ea014ad90cd9fd48

    This study gives a distinct route-reliability result under shared site loss.

  7. supportsTarget pair count agreement in two adult C. elegans brain maps was 26 percent above controls with fixed counts in 2 micrometre cubes sci:sha256:bc6415b7538978df56b50637069e5334760dc88cc607534dbc0caa9575b928a5

    This study finds agreement in adult target group frequencies with spatial count controls.

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