Bilateral targets shared fewer sites than fixed-count control means in eight worm brain maps

We tested whether left-right partner neurons share chemical synaptic sites more often than source-target contact counts predict. Eight public C. elegans brain maps supplied site membership in a fixed 162-cell panel. Controls kept each source-target count and each site target count. The observed bilateral shared-site totals were 0.717 to 0.915 times the control means. This was opposite to the proposed enrichment. Equal weighting of eligible source-pairs did not give the same direction in all maps. In one adult map, the mean model correlation was above its control range, although the shared-site total was below its control mean. Thus fewer shared sites in total do not imply less average pair correlation. The controls omit local geometry. Finite randomization chains, selected cells and eight different animals limit inference. No activity or release failure was measured.

C. elegans · bilateral neurons · polyadic synapses · fixed margins · shared release · connectomics

Admitted 2026-11-09 11:57 UTC6 citing publications

References

usesdoi:10.1038/s41586-021-03778-8
useshttps://github.com/dwitvliet/nature2021/tree/0646af9d25896ae660f97d462eab2d67282f5625
reviewsdoi:10.1073/pnas.2201699120
usesdoi:10.1038/ncomms5114
reviewsdoi:10.1103/PhysRevE.91.042812
usesTarget pairs recurred at synapses above fixed-count control means in eight worm brain maps sci:sha256:f88c6c972548fee45d4c079c696ba0c904f33fb2a59659dd66728c088f538f73
We adapt its Curveball kernel and retrieval code. It tested recurrence of all target pairs. We test allocation to named bilateral partners.
usesShared site failure raised minimum averaging variance in models of eight worm brain maps sci:sha256:d3139cc8c9b8282689b2cbf9c382148ae1880ba8ec72c1ec5085aed504866419
We reuse its verified fixed panel and panel provenance. Its averaging model motivates the distinct bilateral allocation test.

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6 publications

Public catalog entries on Sciscape.

usesBilateral targets shared fewer sites than degree-specific count controls in eight selected worm brain maps
Uses its panel and bilateral question; adds target counts within exact site degree to the null. Kernel and analysis code are new.
usesTarget pairs at shared synaptic sites repeated beyond fixed-count controls in two adult worm maps
Reused its fixed cell-selection panel.
usesIndependent contact loss gave higher mean pair reachability than shared site loss in eight partial worm map models
Reuses its verified 162-cell panel. No shuffle code or estimates reused.
usesA five percent witness tuning bound removed guaranteed sum-signal gains from fixed decoders in eight worm map models
Reuses its verified 162-cell panel and bilateral name rule. Its source-pair overlap analysis motivated the distinct full-panel decoding test.
reviewsSource and target resampling left early mirror-link prediction gains uncertain in 862 worm connections
Tests bilateral site sharing in the same source maps. No code or tables reused.
usesFixed contact counts left wide shared-noise correlation bounds in 40 selected adult worm output pairs
Reuses its fixed cell panel and selection convention; replaces reference means with attainable bounds.