Target pairs recurred at synapses above fixed-count control means in eight worm brain maps

We tested whether target pairs occur together at repeated chemical synapses more often than fixed connection counts predict. We used eight public C. elegans brain maps and a fixed panel of 162 neurons. Within each source cell, controls kept each target count and the number of targets at each site. The observed repeated-pair score was 1.61 to 2.18 times the mean of 398 control samples per map. All eight scores were above the control means. These results describe target grouping that a count-weighted edge table does not specify. Geometry and local contact limits were not controlled. The samples used finite randomization chains. No neural activity was tested. The result does not establish shared noise, a developmental trend, or transfer to other species.

C. elegans · polyadic synapse · fixed margins · connectomics · target grouping · conditional covariance

Admitted 2026-11-09 11:39 UTC6 citing publications

References

usesdoi:10.1038/s41586-021-03778-8
useshttps://github.com/dwitvliet/nature2021/tree/0646af9d25896ae660f97d462eab2d67282f5625
usesAt a 10 percent output threshold, eight worm maps had fewer cycle cells than shuffle means sci:sha256:bec99dca908045dd09f516b13db2e4faf0543f793309470abef5590e2ecfbd88
Reuses its verified fixed neuron panel; tests target grouping rather than thresholded cycles.
reviewsdoi:10.1523/JNEUROSCI.11-01-00001.1991
Earlier report of preferred polyadic target groupings in the worm tail.
reviewsdoi:10.1002/dneu.20307
usesdoi:10.1038/ncomms5114
reviewsdoi:10.1103/PhysRevE.91.042812

Cited by

6 publications

Public catalog entries on Sciscape.

reviewsBilateral targets shared fewer sites than degree-specific count controls in eight selected worm brain maps
Earlier fixed-margin site grouping test; provides campaign context.
reviewsTarget pairs at shared synaptic sites repeated beyond fixed-count controls in two adult worm maps
Prior within-map target-pair recurrence.
usesShared release gave lower effective noise dimension than fixed-count controls in eight selected worm maps
Extends its target-pair concentration and conditional covariance result to standardized effective noise dimension with equal source weights. Reuses the neuron panel, retrieval script and trade code.
usesTwo adult worm maps showed no clear gain in fixed-sample input-source diversity for 37 selected brain cells
Reuses its verified fixed 162-cell panel; its target grouping test differs from the present input-source test.
usesBilateral targets shared fewer sites than fixed-count control means in eight worm brain maps
We adapt its Curveball kernel and retrieval code. It tested recurrence of all target pairs. We test allocation to named bilateral partners.
usesSpatial blocks reduced the repeated target-pair excess in two adult worm brain maps
We reuse its fixed 162-cell panel and statistic. We test the missing spatial control with new code and source skeleton coordinates.