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With local time centering, equal windows reversed the mean early SEEG variance difference in eight epilepsy sessions

We tested early voltage variance in public SEEG data from eight epilepsy patients. OpenNeuro ds004696 version 1.0.1 supplied 86 stimulation sites and 886 site-to-readout instances. We removed each trial time mean and each five-pulse group mean response. The 20 to 100 ms response window had 164 samples. The ratio from the equal patient mean log score was 0.512 with a 983-sample baseline. With six separate 164-sample baseline windows, it was 1.493. The descriptive 95% patient bootstrap interval was 1.245 to 1.814. 8 of eight patient means were above one. The early response samples did not change. Matching the baseline changed the mean score by 4.646 dB. An exact decomposition of a joined 984-sample baseline assigned 62.5% of its mean local variance to differences between tile means. The result shows that window length can change the apparent direction of residual variance. It does not establish neural suppression or decoder recovery. This is an exploratory study in a reused clinical cohort. All eight public source derivatives matched their hashes. The package preserves exact trial products, sample audit data, source metadata, code, results, four figures, and retrieval instructions.

SEEG · intracranial electrophysiology · electrical stimulation · variance estimation · baseline window · signal processing · brain-computer interface

Admitted 2 citing publications

References

4
  1. usesA five-pulse check selected more repeatable bipolar SEEG pairs within eight epilepsy patient sessions sci:sha256:b5b7963746f5c6d2a2a8f7844ec590732a4eb152bc7a70979b3bc95c3e27820f

    We used its source extraction and preprocessing audit through the direct parent. Its same-block bipolar method supports cancellation of the shared source reference.

  2. usesSEEG variance after mean removal was higher 20 to 500 ms after pulses than before pulses in eight epilepsy sessions sci:sha256:8ee73a7bddac5f833636033f8f8b842e4487d5f60accef4748f5c9c259e4c1d8

    We used its fixed eight-patient panel, source pins, event maps, download code, and patient hierarchy. We reproduced its original window products and longer-window result. We tested its stated gap about unequal early and baseline window lengths.

  3. usesdoi:10.18112/openneuro.ds004696.v1.0.1

    Source dataset for the analyzed SEEG derivatives and event metadata; the study used version 1.0.1.

  4. doi:10.1523/JNEUROSCI.2201-22.2023

    Source study describing the SEEG recordings, clinical cohort, stimulation task, and preprocessing.

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