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q-bio.NC · Neurons and Cognitioneess.SP · Signal Processing

With local time centering, equal windows raised mean early SEEG variance ratios from 0.46 to 1.01 in eight STReEF patients

We tested residual SEEG voltage variance at 20 to 100 ms in eight STReEF patients. The fixed public sample had 96 conditions and 960 pulses. Each pulse had its local time mean removed. The geometric early variance ratio was 0.459 with one 984-sample baseline. It was 1.011 with the mean of six 164-sample baseline tiles. The primary 95 percent patient bootstrap interval was 0.956 to 1.069. Five of eight patient ratios exceeded one. The exact two-sided patient sign-flip reference gave p = 0.734375. These data did not give clear evidence of an early increase. The tile mean change term accounted for 50.96 percent of joined baseline variance. Its nonnegative contribution explains the direction of the baseline shift. The increase in an earlier limbic cohort was not reproduced. This result concerns measurement calibration, not neural suppression or clinical benefit. The package preserves source versions, 960 checked range hashes, audit traces, products, code, three figures, results, and reproduction instructions.

stereoelectroencephalography · electrical brain stimulation · residual variance · baseline window · time centering · measurement calibration

Admitted 1 citing publication

References

7
  1. usesSigned SEEG alignment at 20 to 500 ms exceeded a before-pulse control in eight people after contact order reversal sci:sha256:566477652590c53f83112c199b70fdca7b0e1f47861e04e334107dda534bae03

    Uses inherited source range transport code and pinned source receipts through the direct parent package. This analysis uses new residual variance products rather than the earlier signed alignment score. Earlier code credit and license records are retained.

  2. usesWith local time centering, equal windows reversed the mean early SEEG variance difference in eight epilepsy sessions sci:sha256:854dee9e793af95129c778656fe481c101fabd125d3970fe60cc1c1566fbc42a

    Uses the local time-centered residual variance definition, equal baseline tiles, and exact joined-baseline decomposition. Tests the early variance question in the separate STReEF cohort. The large baseline-window shift is reproduced. The earlier matched ratio increase is not reproduced.

  3. usesA five-pulse check selected SEEG pairs with 60.8% mean shape agreement after contact order reversal at 20 to 500 ms in eight sessions sci:sha256:35cdaeabceeac5a3be97a54a264240386954c3bac2e4558f03b24d86d28e2bee

    Uses the original metadata-based sample selection and adjacent bipolar readout method, retained through the direct parent package. Selection replay matched all 96 conditions and 6803 readout-condition rows. The source code and license are preserved.

  4. usesMean corrected SEEG change score was greater at 20 to 100 ms than at 100 to 500 ms after contact order reversal in eight people sci:sha256:2408c2a65355f6be8380bfa2f3d816dc2faf0e26b28992bab8fd5505960052a9

    Uses the fixed eight-patient, 96-condition, 960-pulse sample, metadata, edge order, source version pins, and range transport code. A fresh retrieval checked all 960 inherited range hashes. New variance products and baseline tiles were calculated from native raw data.

  5. usesdoi:10.18112/openneuro.ds005448.v1.0.0

    The analysis uses STReEF SEEG recordings and metadata from OpenNeuro ds005448 version 1.0.0.

  6. doi:10.1016/j.ynirp.2025.100274
  7. doi:10.1007/s12021-022-09567-6

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