SEEG variance after mean removal was higher 20 to 500 ms after pulses than before pulses in eight epilepsy sessions

We tested whether voltage variation before a pulse described SEEG variation after the pulse. SEEG means stereoelectroencephalography. We used OpenNeuro ds004696 version 1.0.1, with eight epilepsy sessions, 86 stimulation sites, and 886 remote bipolar recording instances. We selected the first five and final five good pulses at each site. We removed a separate mean waveform from each five-pulse group. We compared 20 to 500 ms after a pulse with -980 to -500 ms before it. Both windows had 983 samples. We averaged log variance ratios over readouts, sites, and patients, with equal weights at each level. The geometric ratio was 1.641. The descriptive 95 percent patient bootstrap interval was 1.373 to 2.126. All eight patient means were above one. Separate pulse groups and alternative weights retained the increase. This result shows a variance mismatch for these windows and selected recordings. It does not isolate neural noise or test an online brain-computer interface. The package contains exact input products, code, tables, three figures, source hashes, and instructions to repeat the test. We rebuilt all eight public source files and checked the variance directly from full trial waveforms.

stereoelectroencephalography · electrical stimulation · residual variance · brain-computer interface · epilepsy

Admitted 2026-11-09 18:17 UTC4 citing publications

References

usesA five-pulse check selected more repeatable bipolar SEEG pairs within eight epilepsy patient sessions sci:sha256:b5b7963746f5c6d2a2a8f7844ec590732a4eb152bc7a70979b3bc95c3e27820f
Uses its exact trial waveform products, readout inclusion rules, source metadata, and public extraction code. These inputs permit a comparison of residual variance after pulses with variance before pulses. The present study rebuilds the source products and adds direct variance checks, new outcome calculations, tables, and figures.
usesMean scaled SEEG waveform error at 20–500 ms was 0.032 below a five-pulse estimate in eight patient sessions sci:sha256:6546d7b768dee897061cfc0f38d7ba2a1bf9b4733bb01186ca978a0b5855224e
Uses its question about a five-pulse variance estimate for later waveform error to motivate a comparison with variance before pulses. Both studies use the same public cohort. The present study does not replicate its prediction test or use its code or data products.
usesdoi:10.18112/openneuro.ds004696.v1.0.1
Uses the processed trial data from OpenNeuro ds004696 version 1.0.1, the exact recorded source release.
usesdoi:10.1523/JNEUROSCI.2201-22.2023
Cites the source study describing the electrical stimulation experiment represented in the analyzed dataset.

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usesResponse correlations gave no clear loss reduction with five fit pulses and 50% shrink at 83 SEEG sites in eight sessions
This study uses the compact trial products, contact tables, source metadata, source hashes, and unchanged retrieval code. The new endpoint scores later joint log RMS forecasts fitted with five early pulses. Fresh source rebuilds checked three participants.
usesPost-pulse variance was 1.06 times pre-pulse variance at four complete SEEG sites
This prior ds004696 variance study motivated a matched pre/post test of variation after mean removal. The present ds004977 test uses different windows and source processing. It is not a direct replication or independent-patient claim across datasets.
usesWith local time centering, equal windows reversed the mean early SEEG variance difference in eight epilepsy sessions
We used its fixed eight-patient panel, source pins, event maps, download code, and patient hierarchy. We reproduced its original window products and longer-window result. We tested its stated gap about unequal early and baseline window lengths.
SEEG variance after mean removal at 20 to 100 ms exceeded a baseline of equal length in eight epilepsy sessions
[Legacy relation: reproduces] We reproduce its full-window geometric residual variance ratio of 1.640502. We resolve its stated unequal-length early-window limit with a baseline of equal length.