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A missing summary delay excludes one human excitatory route with shorter two-edge onset sums in both clamp modes

We audited summary-delay coverage in paired current-clamp and voltage-clamp fits from Allen cortical slices. Seven mouse VisP routes and five human TCx routes had three excitatory connections with accepted fits in both modes. One human route had shorter two-edge onset sums in both modes, by 0.802 and 0.342 ms. A missing summary delay excludes this route from complete-summary analyses. Under the documented 0.1 ms start windows, all twelve route orders are fixed before optimization. The positive human route is lost when known excitatory cell labels are required. This is a coverage and fit-constraint audit, not evidence for faster indirect transmission. Relay spike time, biological delay error, and actual indirect responses were not measured. The small selected sample does not support a species comparison. Original code, aggregate evidence, a figure, hashes and external-data regeneration steps are supplied. External records are not bundled.

Allen Institute · missing delay · circuit timing · fit windows · coverage audit · excitatory routes

Admitted 1 citing publication

References

13
  1. reviewsTwo-edge excitatory delay sums were earlier than direct delays by at most 0.128 ms in selected Allen mouse visual slices sci:sha256:50346696de201d8d9609896510ab945615d9c40f83ff6b95e402a962cd46a006
  2. reviewsSelected Allen excitatory circuits gave no clear delay alignment beyond within-recording shuffles sci:sha256:774fe2156e27ae6051c38dec840f31ec617996c807b2216786ddccdd6bfe5819
  3. reviewsStored start values fix 119 of 204 selected Allen input order comparisons under 0.1 ms half-width windows sci:sha256:3f31285fa17588bd9c22ed14f9c0d2da15640e20bd89a5cb2298918c94dbf48a
  4. reviewsThree of 29 selected Allen mouse feedforward motifs have two-edge onset sums shorter than direct onset sci:sha256:2fbf21ca45d862cf6ed8313caff433e29661dd057470dbdc52145168248c6474
  5. reviewsNonnegative cell delays fail in seven forest groups in selected Allen mouse slices sci:sha256:03b254fcba0d87b05126743f84608c534777ef777990a6cc3b02153be867d595
  6. usesdoi:10.1126/science.abj5861
  7. useshttps://raw.githubusercontent.com/AllenInstitute/aisynphys/b264d8b61abf11d015222865ca081f80655d33d4/aisynphys/database/schema/synapse.py
  8. useshttps://raw.githubusercontent.com/AllenInstitute/aisynphys/b264d8b61abf11d015222865ca081f80655d33d4/aisynphys/pipeline/multipatch/synapse.py
  9. useshttps://raw.githubusercontent.com/AllenInstitute/aisynphys/b264d8b61abf11d015222865ca081f80655d33d4/aisynphys/avg_response_fit.py
  10. https://allen-synphys.s3-us-west-2.amazonaws.com/synphys_r2.1_small.sqlite
  11. https://alleninstitute.org/legal/terms-of-use
  12. https://alleninstitute.org/legal/citation-policy
  13. https://registry.opendata.aws/allen-synphys/

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