In 5 bilateral ds006253 patients, equal-count left and right SEEG high-gamma pairs showed no significant movement-detection difference (AUC 0.756 vs 0.723; p = 0.50)

We compared left- and right-hemisphere stereoelectroencephalography (SEEG) high-gamma pairs for detecting mouse-movement onset in 15 patients from OpenNeuro ds006253. We used author-provided 70–150 Hz features and a pre-registered, time-ordered detector: movement from 0 to 0.5 s after onset versus rest in the 0.5 s before the stimulus, with the first 60% of trials for training and the last 40% for testing. Hemisphere was assigned from the sign of the x coordinate of each bipolar pair; pairs crossing the midline or lacking coordinates were excluded. In the five patients with at least two pairs on each side, equal-count left-only and right-only pairs had mean test AUCs of 0.756 and 0.723 (mean left-minus-right difference +0.032; left higher in 3/5; exact two-sided sign-flip p = 0.50). With five patients, the smallest possible p was 0.0625, so this test had very low power. Combining both hemispheres exceeded left-only AUC by 0.121 in all five patients (p = 0.0625; Holm-adjusted p = 0.125) and right-only AUC by 0.071 in four of five (p = 0.125; Holm-adjusted p = 0.125). Among ten unilateral implants, mean AUC was 0.801 for left-only (n = 5) and 0.791 for right-only (n = 5), a descriptive comparison. The dataset does not report response hand; interpreting left as contralateral assumes right-hand mouse use. The results do not show equivalence and do not exclude a small or moderate contralateral advantage.

stereoelectroencephalography · SEEG · high-gamma activity · movement onset · hemisphere · mouse movement · AUC · neural decoding