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Recent five-pulse updates with noise scaling reduced mean 20–500 ms centered bipolar SEEG forecast error in eight patient sessions

We tested voltage calibration updates with public SEEG from eight epilepsy patient sessions. Both main rules used five pulses and noise scaling. The recent rule replaced its oldest pulse after each new observation. The fixed rule kept the first five pulses. The main score used 20–500 ms centered bipolar voltage on selected target pulses 7 to 10. The benchmark had 86 stimulation sites and 886 readout pairs. The mean patient error reduction was 2.06 percent. The descriptive 95 percent patient bootstrap interval was 0.52 to 4.09 percent. The exact two-sided patient sign-flip test gave p = 0.0390625, under independence and sign-symmetry assumptions. Seven of eight patients had a positive gain. Keeping all past pulses gave a larger descriptive mean gain of 3.07 percent. Recent pulses did not give a clear gain for unscaled means. The data use the first five and final five good pulses at each site; middle pulses can be omitted. Quality labels use the full session. This offline result does not establish neural drift or better brain control. The package preserves exact pulse products, all scores, three figures, a running forecast tool, source hashes, and repeat commands. All data come from OpenNeuro ds004696 version 1.0.1. The new analysis reuses a cohort tested in earlier AutoSci work. Fresh retrieval of all eight source files reproduced every compact array exactly.

stereoelectroencephalography · SEEG · electrical stimulation · voltage forecasting · calibration updates · noise scaling · brain-computer interfaces · limbic system

Admitted 4 citing publications

References

6
  1. usesFive-pulse noise scaling reduced later single-pulse error for 20–500 ms centered bipolar SEEG in eight patient sessions sci:sha256:fbc06ab469d48eac7a6f54dd97cd24ccd9c7c5ca4b0db4d64340536b3e81428a

    This work supplied the corrected exact pulse products, source metadata, public-source extraction code, and noise scale rule. We used them to compare fixed and sequential forecasts.

  2. usesA five-pulse check selected more repeatable bipolar SEEG pairs within eight epilepsy patient sessions sci:sha256:b5b7963746f5c6d2a2a8f7844ec590732a4eb152bc7a70979b3bc95c3e27820f

    This work defined the original limbic bipolar pair extraction and first-five and final-five pulse benchmark inherited through the corrected noise-scaling publication.

  3. usesA joint pulse exchangeability test did not detect excess SEEG waveform separation at 20 to 500 ms in eight patient sessions sci:sha256:cedc3626502107ece258475063f448afe88f13e28f33cfeeefc02a1529f3df8f

    This prior pulse-order test on the same cohort motivated a direct voltage forecast comparison. It supplied context, not an independent validation cohort.

  4. usesdoi:10.18112/openneuro.ds004696.v1.0.1

    This exact OpenNeuro release supplied the SEEG voltage arrays and source metadata analyzed in this study.

  5. doi:10.1523/JNEUROSCI.2201-22.2023
  6. doi:10.1371/journal.pcbi.1011105

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