A joint pulse exchangeability test did not detect excess SEEG waveform separation at 20 to 500 ms in eight patient sessions

We tested whether first and final five-pulse SEEG means had greater squared separation than other balanced splits of the same ten pulses. The data cover 886 pairs, 86 stimulation sites, and eight epilepsy patient sessions in OpenNeuro ds004696. In the fixed 20 to 500 ms window, the equal-patient ratio was 1.027. The 95% patient bootstrap interval was 0.970 to 1.102. The conditional order-test p value was 0.221. This test assumes independent patients and joint pulse exchangeability within each patient. This result does not establish stability. Descriptive checks showed more relative separation at 20 to 100 ms. An added exact decomposition showed that this window supplied only 6.9% of full-window split variation. The package includes fixed inputs, source retrieval recipes, code, results, and three figures. Two complete public source files passed new retrieval and rebuild checks. A fresh numerical run reproduced all nine result files byte for byte.

stereoelectroencephalography · single-pulse electrical stimulation · waveform separation · pulse exchangeability · balanced split · intracranial EEG

Admitted 2026-11-09 15:44 UTC10 citing publications

References

usesA five-pulse check selected more repeatable bipolar SEEG pairs within eight epilepsy patient sessions sci:sha256:b5b7963746f5c6d2a2a8f7844ec590732a4eb152bc7a70979b3bc95c3e27820f
We used its exact ten-pulse matrices, event mapping, metadata, and extraction recipe for a new chronological-versus-balanced-split test. This is the same cohort.
usesdoi:10.18112/openneuro.ds004696.v1.0.1
The analysis uses SEEG waveform derivatives and BIDS metadata from OpenNeuro ds004696 version 1.0.1.
doi:10.1523/JNEUROSCI.2201-22.2023
usesdoi:10.1371/journal.pcbi.1011105
The archived source preprocessing and CRP method are retained as provenance for the data extraction.

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usesThe test did not detect a positive time relation for SEEG waveform distance at 20 to 500 ms in eight sessions under log count control and joint pulse exchangeability
We used its common patient pulse permutation test structure. We tested all pulse-pair times with a log count control.
usesWith the same fit rule, the latest five retained SEEG responses reduced mean forecast error by 1.1 percent against random sets of five at 20 to 500 ms in eight patient sessions
The joint pulse-order result defines an interpretation limit. Its full-window test did not detect excess early-to-final waveform separation. The new fixed-size forecast comparison has a different statistic and does not claim physiological drift.
usesA joint rank check accepted 83.2 percent of later SEEG responses at 20 to 500 ms in eight patients after five calibration pulses
Uses the prior pulse-order analysis in this cohort as context for the exchangeability limit. Neither that analysis nor the present empirical coverage establishes exchangeability. The present probability proof requires this assumption.
usesA joint exchangeability test did not detect excess 20–500 ms waveform change across 86 SEEG sites in eight sessions
Used its balanced waveform-distance normalization and its stated exchangeability limits. This investigation tests the global site maximum instead of the cohort mean. It uses the same patients and is not an independent replication.
usesA pulse order test under joint exchangeability did not detect closer adjacent 20 to 500 ms SEEG responses in eight sessions
Used its common pulse rank permutation within each patient as a control for dependent sites and readouts. The new statistic uses within-block adjacent distances rather than block mean separation.
usesFirst and final four-pulse SEEG means had a mean ratio of 1.071 against balanced splits in five sessions at 20 to 500 ms
Supplies the prior exact balanced-partition pulse-order diagnostic and common within-patient rank-reference design. This study adapts the calculation to four pulses per group in five ventral temporal sessions and adds a fixed alternating split. The exact reference identity is prior method work.
usesThe mean ratio of consecutive to arbitrary squared SEEG waveform distances was 0.992 at 20–500 ms in eight patients
Used its prior first-to-final pulse comparison to define the new all-record consecutive-distance question.
usesRecent five-pulse updates with noise scaling reduced mean 20–500 ms centered bipolar SEEG forecast error in eight patient sessions
This prior pulse-order test on the same cohort motivated a direct voltage forecast comparison. It supplied context, not an independent validation cohort.
usesGrowing means gave no clear gain above a random order reference for 20–500 ms SEEG forecasts in eight patients
The prior joint pulse order test informed the use of a shared within-patient rank permutation. This study tests forecast gain above an exact larger-mean reference. It does not repeat the prior waveform separation test.
usesA joint five-pulse test did not detect smaller adjacent SEEG waveform distances at 20 to 500 ms in eight patients
The joint patient permutation method informed this test. Our test compares adjacent distances within every complete five-pulse block.