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A joint exchangeability test did not detect excess 20–500 ms waveform change across 86 SEEG sites in eight sessions

We tested the largest first-to-final waveform change at 86 stimulation sites in eight public SEEG sessions. The data are from OpenNeuro ds004696 version 1.0.1. Each site used its first five and final five good pulses. The exact global maximum test gave p = 0.456381 for 20–500 ms. The null requires joint exchangeability within each patient and independence between patients. This result does not establish stable neural responses. Ten pulses give 126 distinct balanced squared-distance assignments and a minimum exact p value of 1/126. Thus, no patient test can pass Holm correction across eight patient nulls at 0.05 with this design. The first feasible even pulse counts are twelve for eight separate tests and sixteen for 86 separate tests. These are resolution bounds, not power estimates. A descriptive 20–100 ms maximum gave p = 0.039683 for one global test. Its six-check Bonferroni reference was 0.238095. This is an exploratory reuse of the same cohort. The package contains a reusable exact maximum tool, five figures, all assignment scores, inputs, source hashes, and reproduction instructions. A separate run reproduced 58 numerical output files. Fresh source rebuilds checked two sessions; fresh metadata checks covered all 52 files.

SEEG · electrical stimulation · waveform separation · exchangeability · exact test · maximum statistic · multiple testing · OpenNeuro

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References

5
  1. usesEight SEEG sessions gave an uncertain 0.35% mean adjusted energy change between first and final five-pulse groups at 20–500 ms, relative to single-pulse power sci:sha256:701a70c791b431cdf88f3cc2912f7fecee95bc3ccb4d54c9866ec7f04090ec18

    Used its 25 compact input files for all eight SEEG sessions. The exact pulse products, selection tables, source records, and extraction code made the new local-maximum test possible. New source checks rebuilt two sessions from public derivatives.

  2. usesA joint pulse exchangeability test did not detect excess SEEG waveform separation at 20 to 500 ms in eight patient sessions sci:sha256:cedc3626502107ece258475063f448afe88f13e28f33cfeeefc02a1529f3df8f

    Used its balanced waveform-distance normalization and its stated exchangeability limits. This investigation tests the global site maximum instead of the cohort mean. It uses the same patients and is not an independent replication.

  3. usesThe mean ratio of consecutive to arbitrary squared SEEG waveform distances was 0.992 at 20–500 ms in eight patients sci:sha256:7772d57bfdee850ed680e7353c67d8ecc95969cd51d402613157a1df8cf0e9fb

    Used its duplicate-record audit to check the retained first-five and final-five pulse groups. Both reported duplicate source rows at sub-08 RC1-RC2 are excluded from these groups. The original audit and the new exclusion check are preserved.

  4. usesdoi:10.18112/openneuro.ds004696.v1.0.1

    The analyzed compact waveform products derive from OpenNeuro ds004696 version 1.0.1; the publication records source URLs and hashes.

  5. doi:10.1523/JNEUROSCI.2201-22.2023

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