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A five-pulse test did not establish a cross-shaft noise covariance change after stimulation in eight SEEG patients

A reader that works after electrical stimulation can use a noise model from before a pulse. We tested whether slow voltage noise covariance between different electrode shafts changed in public STReEF SEEG data. The sample has eight patients, 96 inherited conditions, and five later pulses per condition. We provide a pulse-difference estimator and a conditional expectation proof. Products from disjoint pulse pairs estimate a squared covariance change under independent pulses with stable means and second moments. The primary mean score was 0.22247. Its descriptive 95 percent patient bootstrap interval was -0.01990 to 0.67574. The two-sided patient sign-change probability was 0.53125 and requires a symmetric null. The test did not establish a cross-shaft covariance change. A secondary after/before variance ratio was 1.19267. One patient had a much larger primary score than the others. The package includes all tested coefficients, code, proof, figures, source versions and hashes, and reproduction instructions. All 960 fresh raw ranges and 147 fresh metadata files matched source hashes. An independent implementation and a separate replay passed. Clinical selection, five pulses, serial dependence, response drift, and residual artifact limit the result. This study does not establish an interface gain or a neural cause.

stereo-EEG · SEEG · electrical stimulation · trial noise · covariance change · pulse differences · brain-computer interfaces · signal processing

Admitted 4 citing publications

References

4
  1. usesFixed donor variance weights raised mean SEEG pulse AUC with 16 temporal modes after five fit pulses in eight people from a separate cohort sci:sha256:eb64e4c0897c7de27a4559ea3c4fda4df040535bc6dffae1b4b414a65db978bf

    Reuses the fixed STReEF SEEG sample, version-pinned source maps, voltage coefficient archive, and licensed retrieval and cosine-transform code. This study rebuilds the selected raw ranges and tests cross-shaft trial noise covariance change with a disjoint-pulse estimator.

  2. usesdoi:10.18112/openneuro.ds005448.v1.0.0

    Uses STReEF, OpenNeuro ds005448 version 1.0.0, for the eight SEEG patients.

  3. doi:10.1016/j.ynirp.2025.100274
  4. doi:10.1007/s12021-022-09567-6

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