Fixed donor variance weights raised mean SEEG pulse AUC with 16 temporal modes after five fit pulses in eight people from a separate cohort

Fixed variance weights from eight donors improved signed pulse ranking in a separate SEEG cohort. The test used 16 temporal modes, five fit pulses, and five later test pulses. The target had eight people and 6,803 readout conditions. Mean AUC rose from 0.6100 to 0.6216. Seven people improved. The exact two-sided sign-flip p value was 0.015625. The test treats the donor matrix as fixed and assumes independent, sign-symmetric person differences under the null. The descriptive bootstrap interval for the mean gain was 0.00645 to 0.01661. Before-pulse calls rose from 16.81 to 16.95 percent. Selection was retrospective. The result applies to a fixed ranking rule. It does not establish neural detection or clinical interface performance. Source ranges, code, features, donor inputs, scores, two figures, and offline replay instructions are preserved.

SEEG · electrical stimulation · signal processing · pulse response · AUC · variance weighting

Admitted 2026-11-09 20:06 UTC2 citing publications

References

usesA scale from five early pulses reduced full template SEEG error at 20 to 500 ms after contact order reversal in eight people sci:sha256:c50236eb3980bc5de34015c4d5cd7787844c23bfd051cf18a9adcfe20685512d
Uses the fixed 96-condition, 6,803-readout target sample, raw range receipts, source metadata, audit waveforms, and retrieval helper. New source reads verify all 960 ranges before an independent donor-weight comparison.
usesDonor covariance raised mean 16-mode SEEG response AUC after five local fit pulses at 86 selected sites in eight patients sci:sha256:6c4cced9dadb0e1e3eda59b7313983bcc2e732c773a7d1d9a0363f14681fece4
Uses the fixed 86 donor readouts, archived early background voltages, source event maps, and DCT method. It pools eight donors into one fixed matrix for a separate cohort test.
usesA five-pulse check selected SEEG pairs with 60.8% mean shape agreement after contact order reversal at 20 to 500 ms in eight sessions sci:sha256:35cdaeabceeac5a3be97a54a264240386954c3bac2e4558f03b24d86d28e2bee
Retains the metadata planner and selection check code for the fixed target sample. A replay checks the same 96 conditions and 6,803 readout conditions.
usesdoi:10.18112/openneuro.ds004696.v1.0.1
The fixed donor background variance matrix was rebuilt from archived fit voltages from this version-pinned dataset.
usesdoi:10.18112/openneuro.ds005448.v1.0.0
The eight-person target sample and recorded stimulation responses came from this version-pinned dataset.
doi:10.1523/JNEUROSCI.2201-22.2023
doi:10.1016/j.ynirp.2025.100274
doi:10.1007/s12021-022-09567-6

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usesThe nearest half of SEEG pairs had a higher mean rate of repeatable waveforms across recorded contact order reversal in eight STReEF patients
We reused its checksum-verified metadata sample, pinned source receipts, row maps, audit traces, and MIT retrieval helpers. We freshly retrieved every pulse range and added four-window full-rate waveform products and distance selection results.
usesA five-pulse test did not establish a cross-shaft noise covariance change after stimulation in eight SEEG patients
Reuses the fixed STReEF SEEG sample, version-pinned source maps, voltage coefficient archive, and licensed retrieval and cosine-transform code. This study rebuilds the selected raw ranges and tests cross-shaft trial noise covariance change with a disjoint-pulse estimator.