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The nearest half of SEEG pairs had a higher mean rate of repeatable waveforms across recorded contact order reversal in eight STReEF patients

We tested a fixed distance rule in public STReEF SEEG data. The rule came from a different eight-patient dataset. We used 96 conditions in eight patients. Each condition had five early pulses and five later pulses with reversed recorded contact order. The nearest half of eligible pairs had a mean repeatable waveform rate of 15.6 percent. The exact random expectation at the same pair count was 9.8 percent. The mean gain was 5.8 percentage points. Conditions had equal weight within a patient. Patients had equal weight. All eight patients had positive gains. The same selections had a before-pulse gain of -0.04 points. The patient bootstrap 95 percent interval was 3.4 to 8.3 points. The exact two-sided sign-flip p value was 0.0078, under independent patient gains and a symmetric null. We checked all 960 new raw-data ranges against source hashes. The package preserves full-rate voltage products, source metadata, code, results, and figures. Most selected pairs failed the threshold. The result measures signed waveform shape correlation. It does not prove neural activation, stable amplitude, or a working brain-computer interface.

SEEG · electrical stimulation · waveform correlation · electrode distance · repeatability · STReEF

Admitted 18 citing publications

References

4
  1. The nearest half of bipolar SEEG pairs outside the stimulated shaft had a higher mean rate of repeatable responses than the random expectation in eight epilepsy sessions sci:sha256:1a26d36b188a95ead0d43f052fc29b919849315f46a2562310a4fc08e2efdae2

    [Legacy relation: reproduces] We tested its fixed nearest-half distance rule, signed correlation threshold, and time window in a separate public SEEG cohort. The pulse protocol and eligibility pool differ. The test is an external rule replication, not an identical protocol replication.

  2. usesFixed donor variance weights raised mean SEEG pulse AUC with 16 temporal modes after five fit pulses in eight people from a separate cohort sci:sha256:eb64e4c0897c7de27a4559ea3c4fda4df040535bc6dffae1b4b414a65db978bf

    We reused its checksum-verified metadata sample, pinned source receipts, row maps, audit traces, and MIT retrieval helpers. We freshly retrieved every pulse range and added four-window full-rate waveform products and distance selection results.

  3. usesdoi:10.18112/openneuro.ds005448.v1.0.0

    The analysis used STReEF, OpenNeuro ds005448 version 1.0.0, as its source dataset.

  4. supportsdoi:10.1016/j.ynirp.2025.100274

    This source paper describes the clinical dataset and electrode coordinates.

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