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Global amplitude removal lowered mean site accuracy after recorded contact order reversal in eight STReEF patients with four SEEG pairs

We tested whether response amplitude helps identify a stimulated brain site. We used public STReEF SEEG data from eight patients with epilepsy. Each patient had four tested sites and four selected bipolar recording pairs. Five pulses per site fit each reader. Five separate pulses tested each reader after recorded contact order reversal. The window was 20 to 100 ms after each pulse. Global cosine normalization reduced mean accuracy from 71.9% to 62.5%, a decrease of 9.4 percentage points. Six patients had lower accuracy, and two had higher accuracy. The exact paired sign-flip test gave p = 0.09375. Eight patients give limited evidence for a population difference. Four pair amplitudes alone gave 73.1% accuracy. Positive gain changes from 0.25 to 4 left all normalized reader decisions unchanged in an ideal simulation. This shows a tradeoff between amplitude information and gain invariance in this sample. The package includes figures, all predictions, source code, pinned source records, and a verified raw-data retrieval recipe. The test was retrospective and offline. It did not test perception, online control, or stimulation safety.

stereoelectroencephalography · SEEG · evoked responses · site identification · cosine normalization · signal amplitude · gain invariance · epilepsy · brain-computer interfaces · retrospective analysis

Admitted 11 citing publications

References

5
  1. usesThe nearest half of SEEG pairs had a higher mean rate of repeatable waveforms across recorded contact order reversal in eight STReEF patients sci:sha256:399c1198c4184a27bd9be26923336885a19d4fdd7d9a5d49a4ca8f9cffac5cae

    We used its metadata selection and pinned retrieval helpers through the direct parent publication. These helpers selected the fixed sample and enabled the raw-data rebuild. We retained their license notice.

  2. usesSelection for distinct response patterns had an uncertain mean accuracy gain at four SEEG pairs in eight STReEF patients sci:sha256:143d7f91f05a486692072b6c1e61b67efa46729f12681baae0430cec9016d9ad

    We used its four-site sample in each of eight STReEF SEEG patients. We reused its compact features, source records, and retrieval code. We rebuilt all 320 native epoch ranges. The new analysis compares amplitude and normalized site readers.

  3. usesdoi:10.18112/openneuro.ds005448.v1.0.0

    This exact STReEF release supplied the eight-patient SEEG sample and source metadata used in the analysis.

  4. doi:10.1016/j.ynirp.2025.100274
  5. doi:10.1007/s12021-022-09567-6

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