Response matrix completion reduced error by 2.41% beyond a wiring model in a fixed test of 6,270 C. elegans calcium means
We tested whether other measured responses help complete a C. elegans response atlas beyond a wiring model. We used 6,270 directions with at least six finite stored values. The outcome was the mean of trial-level asinh(x/0.1). The known count panel, neuron terms, positions, local wiring, and wiring profiles formed the main comparison model. We added a centered response matrix fitted only to training residuals, with a nuclear-norm penalty selected in inner folds. Five outer folds kept reverse directions and bilateral class copies together. Mean squared error fell from 0.08361331 to 0.08159535, a 2.41% decrease. All five primary folds had a decrease. A descriptive endpoint-weight range was 0.30% to 5.25%. For 1,855 two-way pairs, sum error fell by 5.14%, but direction-difference error rose by 0.84%. Without the wiring-profile block, response completion decreased error by 7.16%. Adding that wiring block after response completion changed error by +0.28%. None of 19 source-wise residual shuffles matched the primary gain. The export lacks animal and event labels. The result supports conditional response completion within this panel. It does not establish prediction in new animals, a biological matrix rank, or a transmission mechanism. The package preserves source records, code, input facts, fitted states, predictions, figures, and repeat steps.
connectome · Caenorhabditis elegans · signal propagation · matrix completion · response prediction · grouped validation
References
12- usesWiring profiles reduced error by 4.60% after observation count controls in a fixed test of 6,270 C. elegans calcium responses sci:sha256:04992ad78d9cbd9e6f8d2b7915a6159b53153187fe0109abc980f515385005e5
We use its input arrays and baseline code. We reproduce its O and OA test predictions before adding a response matrix correction.
- usesNeuron wiring profiles reduced ridge prediction error by 5.44% in a fixed test of 6,270 C. elegans atlas responses sci:sha256:82205b10c90963e96ba501cad1ac1abbfd2de6ce626ff95dc6c2fbf361413e21
It supplied the original wiring profile benchmark and reused ridge utilities.
- Neuron terms left 86% of the expected cross product between random halves of 6,270 C. elegans response lists after an asinh transform sci:sha256:e2fcb76e66bbd3b6fc0a95dde6d955b0b33aaac2fec9f7b4953d9e5846c5dbf1
It defined the transformed response panel and showed the limits of fixed-list repeat calculations.
- Response sums supplied 81% of the error reduction from two fixed wiring profile models in 1,855 C. elegans atlas pairs sci:sha256:c233e6dbf68a2684cdbab9db262be49cc450be9704ec0a0cf697ea004a2232d6
It separated response sum prediction from direction contrast prediction in earlier wiring models.
- usesNine wiring terms gave no clear gain in a fixed prediction test of same-side response contrasts in 1,381 C. elegans class pairs sci:sha256:41b15854cd8523c5ffd0b63681f8b54798c97d57f265ff77870b2e99ead7941f
It supplied the inherited graph source readers.
- usesdoi:10.1038/s41586-023-06683-4
Randi and colleagues supplied the measured neural activation response atlas.
- usesdoi:10.17605/OSF.IO/E2SYT
This is the signal atlas data record. The exact export commit and file hashes are preserved.
- usesdoi:10.1038/s41586-019-1352-7
Cook and colleagues supplied the primary wiring map, corrected in July 2020.
- usesdoi:10.1098/rstb.1986.0056
White and colleagues supplied anatomical maps used in inherited local feature provenance.
- usesdoi:10.1038/s41586-021-03778-8
Witvliet and colleagues supplied other preserved anatomical maps.
- usesdoi:10.48550/arXiv.0906.2034
The solver follows nuclear-norm matrix completion by singular-value thresholding, with a centering constraint.
- doi:10.1101/2024.09.22.614271
Creamer and colleagues linked anatomy to perturbation time series with a dynamical model. The present task uses static response means and different validation.
Cited by
4 publicationsPublic catalog entries on Sciscape.
- Wiring features reduced calcium response error by 1.17% beyond cell identity in a fixed test across 103 C. elegans worms
This earlier response completion test lacked animal labels. It motivates the present test across animals. The response measure and model differ.
- usesWiring profiles reduced error by 1.65–3.10% with both endpoint groups excluded from training in five fixed C. elegans ridge tests
Its shared cache supplied numerical files and preserved model utilities. We checked their bytes against the signed source package.
- Anatomical paths reduced mean calcium prediction error in 103 C. elegans animals excluded from training
This earlier response-completion test used pooled means without animal labels. The present test keeps complete animals separate.
- usesWith one response hidden, other cells' fluorescence reduced error by 5.4% after wiring and red controls in 92 C. elegans worms
Its signed numerical graph facts give an independent comparison for our complete source rebuild.