Wiring profiles reduced error by 4.60% after observation count controls in a fixed test of 6,270 C. elegans calcium responses
We tested whether wiring profiles help predict calcium responses after a control for observation count profiles. We used 6,270 directed entries from a pinned C. elegans signal atlas export. Each entry had at least six finite trial values. The outcome was the mean signed calcium value after an asinh transform. We compared ridge models with neuron, position, local wiring, and count terms. Added profile products had separate penalties selected within each training fold. Reverse directions and bilateral group pairs stayed in the same test fold. The model with count profiles had mean squared error 0.08764489. Adding wiring profiles reduced error to 0.08361331, a 4.60% reduction. The gain was 4.62% before the count profile control. The control left 99.68% of the absolute wiring gain. Added count profiles alone changed error by less than 0.014%. All specified checks kept a positive wiring gain. The gain was 3.94% when test source groups were excluded from all training responses. This is a conditional response completion result. Count profiles can reflect both recording conditions and biology. The export lacks animal and event labels. The test does not establish accuracy in new animals or a signal transmission mechanism. The package preserves source records, count facts, code, fitted states, predictions, figures, and repeat instructions. A clean replay matched 72 result files.
C. elegans · connectome · signal propagation · observation counts · calcium response · structure and function · group validation · wiring profiles
References
9- usesNeuron wiring profiles reduced ridge prediction error by 5.44% in a fixed test of 6,270 C. elegans atlas responses sci:sha256:82205b10c90963e96ba501cad1ac1abbfd2de6ce626ff95dc6c2fbf361413e21
We reuse its verified numerical inputs and MIT model utilities. We test whether its added wiring gain remains after a new observation count profile control.
- usesNeuron terms left 86% of the expected cross product between random halves of 6,270 C. elegans response lists after an asinh transform sci:sha256:e2fcb76e66bbd3b6fc0a95dde6d955b0b33aaac2fec9f7b4953d9e5846c5dbf1
This study defines the transformed trial outcome and finite-count response panel used in the inherited benchmark.
- usesNine wiring terms gave no clear gain in a fixed prediction test of same-side response contrasts in 1,381 C. elegans class pairs sci:sha256:41b15854cd8523c5ffd0b63681f8b54798c97d57f265ff77870b2e99ead7941f
This is the original source of the inherited MIT graph extraction code.
- usesdoi:10.1038/s41586-023-06683-4
Original neuron activation and calcium response measurements.
- usesdoi:10.17605/OSF.IO/E2SYT
Original signal atlas data record. We use the pinned export specified in the publication.
- usesdoi:10.1038/s41586-019-1352-7
Original whole-animal anatomical data. The tested matrix uses the July 2020 correction.
- doi:10.1101/2024.09.22.614271
Version 4, 18 May 2026, tests a connectome-constrained dynamical model. Its prediction task differs from ours.
- usesdoi:10.1098/rstb.1986.0056
Source of older anatomical facts preserved in the inherited numerical input package.
- usesdoi:10.1038/s41586-021-03778-8
Source of older anatomical facts preserved in the inherited numerical input package.
Cited by
5 publicationsPublic catalog entries on Sciscape.
- usesWiring features reduced calcium response error by 1.17% beyond cell identity in a fixed test across 103 C. elegans worms
We reuse its canonical names and full graph facts, then check the Cook graph against the source workbook.
- usesChemical arrow reversal left profile similarity unchanged with equal input and output weights in five C. elegans maps
Its MIT count-profile model utilities are preserved in the source package and reused here.
- usesWiring profiles reduced error by 1.65–3.10% with both endpoint groups excluded from training in five fixed C. elegans ridge tests
We reuse its verified numerical inputs, ridge model utilities, count profiles, and fixed penalty grid. We reproduce its pair and source exclusion predictions exactly.
- usesResponse matrix completion reduced error by 2.41% beyond a wiring model in a fixed test of 6,270 C. elegans calcium means
We use its input arrays and baseline code. We reproduce its O and OA test predictions before adding a response matrix correction.
- usesWiring profiles reduced ridge test error by 0.64% after exclusion of animals and neuron pairs in 108 C. elegans recordings
The observation-profile kernel follows this prior sampling control.