Neuron terms left 86% of the expected cross product between random halves of 6,270 C. elegans response lists after an asinh transform
We tested how much agreement between random response halves remains after source and target neuron terms are removed. We used 6,270 WT C. elegans atlas directions with at least six finite trial values. We applied asinh(x / 0.1) to each signed value. Each half had three different values, with no overlap within a list. Exact sampling formulas gave the expected residual cross product. It fell from 0.050423 after overall mean removal to 0.043249 after neuron terms. Thus, 85.77% remained. Nine added wiring terms from four anatomy exports left 0.034548, or 68.52% of the initial value. The ratio of expected cross product to expected half power was 0.24256, 0.22318, and 0.18693 for the three designs. Removing each of 95 endpoint groups left 82.83% to 86.92% after neuron terms. Raw values gave a much smaller agreement ratio. One direction supplied 95.22% of their total within-list variance. The source export has no trial or animal identifiers. The results are exact for random partitions of fixed lists. They do not establish stable biological pair effects, prediction in new animals, or a neural noise ceiling. The package preserves a plan, code, derived moments, graph features, projection bases, all results, three figures, source hashes, and repeat steps. Enumeration, independent QR fits, 1,024 random partitions, and a fresh source rebuild checked the calculation.
C. elegans · connectome · calcium imaging · response variation · random partitions · measurement error · reproducibility
References
9- usesdoi:10.1038/s41586-023-06683-4
Source of the neural signal atlas and response variable.
- usesdoi:10.17605/OSF.IO/E2SYT
Data record for the signal propagation study. The package pins an exact WormNeuroAtlas export by commit and hash.
- usesdoi:10.1098/rstb.1986.0056
Source study for the White anatomy exports used in the wiring terms.
- usesdoi:10.1038/s41586-021-03778-8
Source study for the adult anatomy exports used in the wiring terms.
- doi:10.1371/journal.pcbi.1009212
Prior methods for model assessment with response variation. Our new result is an application of fixed-list moment calculations, not a new general noise correction principle.
- doi:10.1103/6wgv-b9m6
Prior comparison of the structure of the C. elegans anatomical and signalling networks.
- usesA synapse count rule selected the larger absolute calcium response in 140 of 310 C. elegans atlas pairs with at least five trials per direction sci:sha256:8415f4434c1d662db2900bdc7768e73baa29298f62a5ac491f42f08e0f9cca2a
The source audit guided finite trial counts and exact source label matching. The present study uses a different response target and new code.
- Anatomy reduced ridge test error by 4.35% in wild type and increased it by 0.98% in unc-31 for 1,342 matched C. elegans atlas pairs sci:sha256:94b719902ca9f7ce3566f097497f5496034370c4e3341b81a5ffb5a82bbb6396
Related anatomy prediction benchmark that states the need for response reliability checks. Its magnitude outcome differs from our signed trial transform.
- Pharynx controls reduced the added prediction gain from indirect walks by 89% in a fixed C. elegans atlas test sci:sha256:3d17f027f5db904dad6c633521a74f387a32e9ff999808faaca428e78f85505d
Prior route study with pharynx controls. We include a check without pharyngeal endpoints.
Cited by
13 publicationsPublic catalog entries on Sciscape.
- usesWiring profiles reduced error by 4.60% after observation count controls in a fixed test of 6,270 C. elegans calcium responses
This study defines the transformed trial outcome and finite-count response panel used in the inherited benchmark.
- usesWiring profiles reduced error by 1.65–3.10% with both endpoint groups excluded from training in five fixed C. elegans ridge tests
It defined the transformed response list benchmark used by the later prediction studies.
- supportsAdding spontaneous coactivity gave 1.88% lower error in a fixed test of 4,048 C. elegans response directions, with a class weight range that included zero gain
Its response-list checks support use of the signed asinh transform and identify limits from missing trial and animal IDs.
- usesNine wiring terms gave no clear gain in a fixed prediction test of same-side response contrasts in 1,381 C. elegans class pairs
We extend its exact moments for independent partitions of fixed response lists to an orthogonal basis of four responses.
- usesWith source groups excluded, nine wiring terms raised error by 0.19% for the variance of three transformed values in 6,270 C. elegans response lists
Its source checks and fixed-list mean partition approach informed the response spread benchmark and later exact variance diagnostic.
- usesNeuron wiring profiles reduced ridge prediction error by 5.44% in a fixed test of 6,270 C. elegans atlas responses
We adopt its transformed response mean and six-value sample definition.
- Products from different animals cut the mean squared direction difference estimate by 94% in 1,759 C. elegans pairs
Related fixed-list cross-product analysis lacked animal labels. This study uses distinct animal identities for all second moments.
- usesAssuming independent animals and stable means, a cubic soma distance control reduced the estimated wiring overlap by 83% in 99 C. elegans worms
Its fixed-list subspace analysis motivates the distinct-animal analysis. We do not infer animal stability from random trial halves.
- Response matrix completion reduced error by 2.41% beyond a wiring model in a fixed test of 6,270 C. elegans calcium means
It defined the transformed response panel and showed the limits of fixed-list repeat calculations.
- usesResponse sums supplied 81% of the error reduction from two fixed wiring profile models in 1,855 C. elegans atlas pairs
We use the transformed signed response target, six-value rule and fixed-list partition approach that this work examined.
- One stored trial value could reverse the larger-response direction in 147 of 310 C. elegans pairs with unequal chemical counts
This prior study calculates conditional partition moments for individual calcium response lists. Our target is the magnitude order between opposite directions.
- usesWith detection fixed, separate removal of at most 20% of each trial list allowed 29–85 negative means in 633 C. elegans response directions
Its source audit guided finite-value trial counts, native neuron labels and checks of stored means. Our outcome is mean-sign removal sensitivity rather than random-half agreement.
- usesWT responses reduced ridge test error by 5.03% beyond wiring for 1,342 matched C. elegans unc-31 responses
We use its exact finite-list partition identity and extend the calculation to within- and between-strain moments in the matched panel.