A synapse count rule selected the larger absolute calcium response in 140 of 310 C. elegans atlas pairs with at least five trials per direction
We tested whether chemical synapse counts identify the direction with the larger absolute mean calcium response within a neuron pair. We used the WT group of the signal propagation atlas compiled on 28 June 2023. Four exported anatomy maps supplied chemical counts. The main sample had 2,446 pairs and 110 neurons. Each direction had at least five usable trial values. Only 310 pairs had unequal chemical counts. The direction with more chemical synapses had the larger absolute response in 140 pairs, or 45.2 percent. A descriptive 95 percent node-weight range was 34.3 to 56.8 percent. It does not establish performance below chance. A fixed logistic model controlled for neuron send and receive effects and unequal trial counts. Adding chemical count differences raised held-out Brier error from 0.245030 to 0.245138. The error reduction was -0.000108. Its fixed-prediction node-weight range was -0.000494 to 0.000244. Other trial cutoffs and four separate anatomy maps also gave raw choice rates below 50 percent. The result applies to these atlas entries. It does not show that anatomy cannot predict function. Mean response noise, indirect paths, strain differences and missing biological factors can affect the comparison. The package preserves the paired benchmark data, source versions and hashes, code, model states, checks, figures and repeat instructions.
connectome · Caenorhabditis elegans · signal propagation · chemical synapse · direction prediction · paired comparison · reproducible benchmark
References
5- usesdoi:10.1038/s41586-023-06683-4
We use the WT-background signal propagation measurements through a pinned Worm Neuro Atlas export.
- usesdoi:10.17605/OSF.IO/E2SYT
This is the source study data record. Our analysis uses the smaller pinned Worm Neuro Atlas matrices. The raw OSF archives remain external.
- usesdoi:10.1098/rstb.1986.0056
Two exported anatomy maps come from this source study.
- usesdoi:10.1038/s41586-021-03778-8
Two adult exported anatomy maps come from this source study.
- doi:10.1103/6wgv-b9m6
Prior work compares anatomy and signal network structure and discusses unequal sampling. Our test compares the two directions within each pair.
Cited by
15 publicationsPublic catalog entries on Sciscape.
- A fixed model gave a 0.000009 mean Brier gain from two-step electrical paths in 15,384 C. elegans atlas pairs
Prior SCI work tested chemical direction counts and documented source identity issues. We independently read the source rows and test two-step path counts.
- Mirror synapse counts did not lower response detection error in 9,725 C. elegans atlas pairs under a fixed logistic model
This study tested count direction against response magnitude. Its source audit identified the usable measurement count rule and unresolved labels.
- usesAt gain 0.5, 33 of 82 signs fixed by uncertainty bounds in a linear C. elegans chemical model opposed measured calcium signs
Its audit informed our finite trial count check. We independently verified the source fields and response direction.
- usesA flag for two-edge chemical routes in an adult map increased Brier error in a fixed model of calcium response detection for 3,293 C. elegans atlas pairs
This prior study identified source orientation and trial-count issues and tested a different function question. We use those source checks and compare with its scope. No source code was reused.
- supportsStable chemical connections across eight C. elegans connectomes did not propagate optogenetic signals more often than variable connections at matched adult synapse count
Our finding that a chemical synapse i->j predicts detection as well as one j->i (7.1% vs 7.3%) agrees with its finding that chemical count direction did not pick the larger atlas response.
- Adding mean synapse volume increased mean prediction error in a fixed test of 632 C. elegans connections
This related study tests count differences against response direction. We add a distinct test of mean size and response detection.
- usesAnatomy reduced ridge test error by 4.35% in wild type and increased it by 0.98% in unc-31 for 1,342 matched C. elegans atlas pairs
Its source audit guided finite trial counts, AWC exclusions, and exact-name CSV parsing. We wrote separate analysis code.
- Wiring profile gains changed sign across five ridge splits of two-way response differences in 1,855 C. elegans atlas pairs
The earlier paired direction benchmark motivates a broader test with continuous signed contrasts and complete wiring profiles.
- usesAdding a count of paths within one map reduced Brier error by 0.000014 in a fixed test of 21,074 C. elegans pairs without recorded direct edges
Its source checks guided our atlas name matching and use of stored trial arrays. We test indirect paths rather than response direction.
- Adult map labels raised Brier error after route count adjustment in 7,554 C. elegans atlas directions
This study provides prior results on direct chemical counts and response direction.
- usesOne stored trial value could reverse the larger-response direction in 147 of 310 C. elegans pairs with unequal chemical counts
We audit its exact opposite-direction target and sample. An independent reader matches its paired input table. We use no source code from that publication.
- Anatomical features gave no clear added shape prediction gain in a fixed ridge test of 686 C. elegans transfer kernels
It tests response size and direction in the same atlas. The current benchmark tests normalized temporal shape.
- Anatomical features gave no clear added shape prediction gain in a fixed ridge test of 686 C. elegans transfer kernels
It tests response size and direction in the same atlas. The current benchmark tests normalized temporal shape.
- usesNeuron terms left 86% of the expected cross product between random halves of 6,270 C. elegans response lists after an asinh transform
The source audit guided finite trial counts and exact source label matching. The present study uses a different response target and new code.
- usesTerms for wiring direction raised Brier error in fixed WT and unc-31 models of 3,261 C. elegans atlas pairs
We extend its WT direction question to matched WT and unc-31 detection models. No prior source code is copied.