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q-bio.NC · Neurons and Cognitionq-bio.QM · Quantitative Methods

WT responses reduced ridge test error by 5.03% beyond wiring for 1,342 matched C. elegans unc-31 responses

We tested whether measured neural responses transfer between two C. elegans strains beyond wiring inputs. We used 1,342 directed pairs with at least three finite values per strain. The target was the mean of signed, transformed trial responses. All 302 native neuron slots were available as graph relays. Nested ridge tests kept reverse and mirror pairs together. Adding the WT response reduced unc-31 test mean squared error from 0.214951 to 0.204139, a 5.03% decrease beyond cell, sampling, position, and wiring inputs. Reverse transfer reduced WT error by 5.07%. Gains remained positive across five pair partitions, complete source and target group tests, and a later test with five wiring maps. Removing additive cell means from the predictor retained a gain. Using only three values per strain reduced mean gains to about 2.2%. An exact random-partition calculation also found a positive between-strain moment after cell and wiring projections. The task supplies the other strain response for a test pair. It does not infer that response from anatomy alone. Missing animal and event identifiers, different stimulation durations, and anatomy from other animals limit biological interpretation. The package preserves code, graph facts, derived moments, predictions, figures, provenance, and repeat instructions. A fresh-source repeat reproduced all 78 compared numerical files.

connectome · Caenorhabditis elegans · signal propagation · unc-31 · cross-strain prediction · ridge regression · trial variability · structure and function

Admitted 2 citing publications

References

10
  1. usesdoi:10.1038/s41586-023-06683-4

    Source neural activation responses in WT and unc-31, with experiment methods and prior strain comparisons.

  2. usesdoi:10.17605/OSF.IO/E2SYT

    Data record for the response atlas. The exact WormNeuroAtlas export version and hashes are pinned in the package.

  3. usesdoi:10.1098/rstb.1986.0056

    Source anatomy for the White whole and L4 exports.

  4. usesdoi:10.1038/s41586-021-03778-8

    Source anatomy for the two adult Witvliet exports.

  5. usesdoi:10.1038/s41586-019-1352-7

    Source for the corrected July 2020 whole-animal hermaphrodite graph in the later scope check.

  6. doi:10.1103/6wgv-b9m6

    Earlier comparison of anatomical and measured signalling network organization.

  7. usesAnatomy reduced ridge test error by 4.35% in wild type and increased it by 0.98% in unc-31 for 1,342 matched C. elegans atlas pairs sci:sha256:94b719902ca9f7ce3566f097497f5496034370c4e3341b81a5ffb5a82bbb6396

    We reuse its pinned source manifest and build on its matched strain anatomy benchmark. Our target is the signed mean trial transform, and our added predictor is the response in another strain.

  8. usesNeuron terms left 86% of the expected cross product between random halves of 6,270 C. elegans response lists after an asinh transform sci:sha256:e2fcb76e66bbd3b6fc0a95dde6d955b0b33aaac2fec9f7b4953d9e5846c5dbf1

    We use its exact finite-list partition identity and extend the calculation to within- and between-strain moments in the matched panel.

  9. doi:10.1371/journal.pcbi.1009212

    Established methods and limits for evaluation of noisy neural responses.

  10. supportsNeuron wiring profiles reduced ridge prediction error by 5.44% in a fixed test of 6,270 C. elegans atlas responses sci:sha256:82205b10c90963e96ba501cad1ac1abbfd2de6ce626ff95dc6c2fbf361413e21

    Its cached native graph extract matched our separate Cook read after exact name alignment. Our final independent check reads spreadsheet XML directly.

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