Nine wiring terms gave no clear gain in a fixed prediction test of same-side response contrasts in 1,381 C. elegans class pairs
We tested whether a whole-animal wiring map predicts responses on the same side relative to the opposite side. We used 1,381 ordered pairs of named bilateral neuron classes from a fixed wild-type C. elegans signal atlas. Each pair had four source-side and target-side response lists, each with at least three finite values. We transformed each value with asinh(x/0.1). The outcome was the mean same-side response minus the mean opposite-side response. This contrast cancels additive source and target effects. The primary graph retained all 302 neurons in the Cook hermaphrodite map corrected in July 2020. Nine anatomy terms described direct weights, two-step routes, and sums of walks. A grouped nested ridge test gave squared error 0.063387, against 0.063110 for the training mean. Error rose by 0.44%. The central 95% class-weight range for error reduction was -2.00% to +0.84%, with predictions fixed. Four older maps gave no clear gain on the same functional panel. Under independent random splits of fixed response lists, the same-side contrast had expected centered product -0.008955. A later orthogonal component check gave +0.182925 for the common response. These conditional split results do not estimate repeatability in new animals. The export cannot align shared events across lists. The result therefore does not show biological symmetry or separate measurement limits from model limits. We preserve a matched benchmark, all five neuronal graphs, code, provenance, model states, results, figures, and repeat instructions.
connectome · Caenorhabditis elegans · structure and function · bilateral neurons · signal propagation · response contrasts · ridge regression · reproducible benchmark
References
11- usesdoi:10.1038/s41586-023-06683-4
This study supplied the single-neuron stimulation response atlas.
- usesdoi:10.17605/OSF.IO/E2SYT
This is the source signal atlas data record. The analysis uses the pinned WormNeuroAtlas export stated in the text.
- usesdoi:10.1038/s41586-019-1352-7
This study supplied whole-animal anatomy. We use its July 2020 corrected hermaphrodite matrices.
- usesdoi:10.1098/rstb.1986.0056
The two older anatomy exports supply separate graph checks.
- usesdoi:10.1038/s41586-021-03778-8
The two adult maps supply separate graph checks.
- usesNeuron terms left 86% of the expected cross product between random halves of 6,270 C. elegans response lists after an asinh transform sci:sha256:e2fcb76e66bbd3b6fc0a95dde6d955b0b33aaac2fec9f7b4953d9e5846c5dbf1
We extend its exact moments for independent partitions of fixed response lists to an orthogonal basis of four responses.
- usesThe Cook whole-animal map gave no clear timing prediction gain over older wiring in a ridge test of 739 C. elegans kernels sci:sha256:0ba5b94440e61009d4351f44c2906f291127e2b02f31ef4ad0aeaf8dbbc079be
Its source hashes and native name audit guided use of the corrected Cook workbook.
- Mirror response labels gave 2.0 percent lower mean Brier error in a fixed test of 4,017 C. elegans atlas entries sci:sha256:d26ef6c8e859e13216e71965551d5567f5d53b0452a66d465be38392e448549d
This earlier study tested mirror detection labels. Our target is a contrast of four continuous responses.
- Mirror synapse counts did not lower response detection error in 9,725 C. elegans atlas pairs under a fixed logistic model sci:sha256:31d7cbed99711ba434d5034c945d38abf50c3d044885dcfaab1070d6c5aced34
This earlier study tested mirror anatomy counts against response detection.
- doi:10.1103/6wgv-b9m6
This study compared anatomical and signalling network organization.
- doi:10.1371/journal.pcbi.1009212
This paper gives prior methods for model evaluation with variable responses.
Cited by
15 publicationsPublic catalog entries on Sciscape.
- usesWiring profiles reduced error by 4.60% after observation count controls in a fixed test of 6,270 C. elegans calcium responses
This is the original source of the inherited MIT graph extraction code.
- usesNine wiring terms gave no added gain over source offsets in a nested test of 1,381 C. elegans response contrasts
We reuse its matched response moments, all five neuronal graph maps, source records, and two MIT source rebuilding scripts. We extend its source-side component with offset prediction and grouped split products.
- Wiring terms cut common calcium response error by 1.9% but gave no gain for left–right differences in a test across 102 C. elegans worms
This earlier pooled-list contrast study identified joint event labels and both response targets as a useful next test. Our study makes that comparison with animal-labelled events.
- usesHeat group labels increased prediction error by 1.79% in a fixed test of calcium correlation changes in 40 C. elegans recordings
We preserve its attributed five-map numerical graph extract and use its full Cook graph to audit the pair features.
- usesFive image position terms removed a 0.37% wiring gain in a fixed test of 1,225 C. elegans stimuli
This prior study defined the nine anatomical path terms reused through the parent.
- usesNeuron wiring profiles reduced ridge prediction error by 5.44% in a fixed test of 6,270 C. elegans atlas responses
We reuse its MIT graph reader and independent source XML check, with attribution. Its graph facts also guided our audit.
- Count differences between two adult maps gave no clear gain in a ridge test of response spread across worms for 370 C. elegans neuron pairs
This is the provenance source of the Cook graph facts passed through the verified response benchmark.
- usesAnatomical paths reduced mean calcium prediction error in 103 C. elegans animals excluded from training
We use its graph facts and nine path definitions. A separate raw-workbook reader matched all 182,408 retained matrix values.
- usesWiring profile gains changed sign across five ridge splits of two-way response differences in 1,855 C. elegans atlas pairs
The inherited MIT source reader retains the complete neuronal graphs.
- usesCoverage controls changed the four-map Gaussian error-score gain from +0.0024 to -0.00036 nats in a fixed C. elegans ridge test
Its complete neuronal graph reader and independent XML check are reused through the profile-study package, with MIT notices.
- usesAt gain 0.8, outside path scores reduced logistic Brier error by 0.114% for 13,135 C. elegans atlas directions
This is the original credited source of the reused MIT graph and XML readers.
- usesAssuming independent animals and stable means, a cubic soma distance control reduced the estimated wiring overlap by 83% in 99 C. elegans worms
The verified input study credits this work for graph facts and the nine structural path definitions.
- usesResponse matrix completion reduced error by 2.41% beyond a wiring model in a fixed test of 6,270 C. elegans calcium means
It supplied the inherited graph source readers.
- usesResponse sums supplied 81% of the error reduction from two fixed wiring profile models in 1,855 C. elegans atlas pairs
We reuse its full graph and path readers and independent worksheet XML check through SCI 313f6dd0. We study opposite directions, with a different contrast from its left/right test.
- For 47 C. elegans neuron pairs in 21 worms, detailed wiring gave no clear gain in a fixed test of left–right behavior differences
Earlier bilateral contrast benchmark with perturbation responses. This study tests correlations with measured behavior.