Mirror response labels gave 2.0 percent lower mean Brier error in a fixed test of 4,017 C. elegans atlas entries
We tested whether a measured mirror response helps predict signal detection in a fixed C. elegans atlas. The main test used 4,017 left-source entries from 72 bilateral neuron classes. Each entry and its mirror had at least three recorded observations. The atlas count can include missing response values. Five fixed folds kept reverse directions and all side copies of each class pair together. The base logistic model used wiring counts, observation counts, soma distance and neuron indicators. Adding the mirror detection label reduced mean test Brier error from 0.053362 to 0.052283. The reduction was 0.001080, or 2.02 percent. A central 95 percent class weight range was -0.000513 to 0.003095. It includes zero and holds predictions fixed. The raw detection rates were 28.91 percent with a detected mirror and 5.05 percent without one. Direct label copying made 397 errors. Labeling all entries negative made 273 errors. Extra wiring and spline controls retained small mean gains. These data do not establish a gain in new animals or symmetry of true neural transfer. The package preserves code, exact source versions, hashes, assay labels, fitted models, predictions, weight draws and figures. Instructions permit inspection and reproduction.
connectome · C. elegans · signal propagation · bilateral symmetry · atlas completion · prediction · Brier error
References
6- usesdoi:10.1038/s41586-023-06683-4
We use the wild-type signal propagation atlas and its assay labels.
- usesdoi:10.1038/s41586-021-03778-8
Two adult anatomical maps supply count inputs.
- usesdoi:10.1098/rstb.1986.0056
The atlas anatomy export includes two maps attributed to this work.
- doi:10.1103/6wgv-b9m6
This study compared anatomical and signal network communities, including bilateral partner membership.
- Stable chemical connections across eight C. elegans connectomes did not propagate optogenetic signals more often than variable connections at matched adult synapse count sci:sha256:5cbb4c1917dff79c9e9f17c6ff6ae5d0ba556de73d1a96c2f13df319c7fef4d0
This prior SCI study compared stable chemical wiring with signal detection in the same functional atlas.
- Mirror synapse counts did not lower response detection error in 9,725 C. elegans atlas pairs under a fixed logistic model sci:sha256:31d7cbed99711ba434d5034c945d38abf50c3d044885dcfaab1070d6c5aced34
This prior SCI study tested mirror chemical counts. We test measured mirror response labels.
Cited by
4 publicationsPublic catalog entries on Sciscape.
- usesConnection frequency across six larval maps changed Brier error by less than 0.04% in two fixed models of 8,265 C. elegans atlas entries
We use its validation principle that reverse directions and side copies of a class pair stay in one fold. The added predictor and analysis code are new.
- usesIn a 30-second window, 315 of 668 selected C. elegans kernels with peaks before one second had most absolute area after one second
It supplies context for grouped bilateral class-pair validation and descriptive class weights. We keep actual neuron identities and weight each distinct endpoint group once.
- Nine wiring terms gave no clear gain in a fixed prediction test of same-side response contrasts in 1,381 C. elegans class pairs
This earlier study tested mirror detection labels. Our target is a contrast of four continuous responses.
- supportsMirror response data cut mean test error by 0.43% in 103 C. elegans worms kept out of fitting
Its fixed-atlas mirror-label result motivates the new-animal test. Our different outcome, panel and split do not constitute a direct numerical replication.