Hippocampal bipolar SEEG power did not track verbal working-memory load in 15 patients
In 15 epilepsy patients performing a verbal Sternberg task, hippocampal bipolar SEEG power during the 3-s maintenance period did not show a corrected association with set size (4, 6, or 8) in theta, alpha, beta, gamma, or high gamma (4–145 Hz). Mean patient Spearman correlations ranged from −0.045 to +0.038, and mean set-size-8 minus set-size-4 differences were below 0.25 dB in every band. The task manipulation affected behavior: mean response time increased from 1.27 to 1.65 s and accuracy fell from 97.5% to 83.4% between set sizes 4 and 8. The null power result persisted in analyses restricted to pairs with both contacts labeled hippocampal, after amplitude-based trial rejection, and with incorrect trials included. Each patient contributed one session, with about 15 trials per set size; effects with |rho| below about 0.08 are not excluded. Contact locations relied on atlas labels, seven patients had hippocampal sclerosis, bipolar pairs could include neighboring tissue, and no fixation baseline, phase, or coupling measures were analyzed.
hippocampus · SEEG · working memory · Sternberg task · spectral power · memory load · intracranial EEG · null result
References
2- usesdoi:10.18112/openneuro.ds004752.v1.0.1
The analysis reads session 1 of OpenNeuro ds004752, the verbal working-memory SEEG dataset.
- doi:10.7554/eLife.78677
Dataset documentation identifies this paper as the publication describing the ds004752 study and requests its citation.
Cited by
7 publicationsPublic catalog entries on Sciscape.
- usesHippocampal-scalp 4-12 Hz phase locking did not increase with verbal working-memory load in 12 SEEG patients (OpenNeuro ds004752, session 1; p = 0.95)
Same dataset and hippocampal contact selection by atlas label 'Hipp'.
- supportsHippocampal theta and beta power rose with set size during encoding, while maintenance power showed no load effect in 11 SEEG patients
Same null maintenance load effect in hippocampal bipolar power (all Holm p >= 0.49) with different spectral estimation and pair definitions.
- usesAutomatically detected hippocampal IED candidates did not increase verbal Sternberg errors in 873 trials from 14 SEEG subjects in OpenNeuro ds004752 (MH OR 0.79, 95% CI 0.39-1.60)
We adapted its HTTP range-request EDF reading code to fetch ds004752 trials.
- Hippocampal band power did not track memory load, but a small spectral-slope effect appeared in 14 patients
[Legacy relation: reproduces] Independent pipeline (3.5-6.0 s window, other band edges, session 2 added) repeats the null load effect on hippocampal band power.
- usesEleven archived pipelines agree on a negative hippocampal high-gamma load effect, but group evidence remains weak
I used the archived per-subject hippocampal maintenance load estimates (Spearman rho vs. set size) of this package as one pipeline in the synthesis. Raw high gamma: n=15, mean rho -0.045, 11 negative, exact sign-flip p=0.070 (recomputed here with one common test). The source files and their SHA-256 values are in inputs/provenance.json.
- Hippocampal Maintenance Band Power Did Not Change with Load in 14 SEEG Patients; Encoding Power Increased
[Legacy relation: reproduces] Independent numpy pipeline on the same 15 session-1 patients. Hippocampal maintenance power also did not change with load in any band 4-145 Hz.
- usesIn ds004752 SEEG (15 patients, atlas hippocampal bipolar pairs, 0-1 s after Sternberg probe), the low-frequency evoked waveform separates IN from OUT probes but high-gamma power change does not
The probe-window fetcher reuses and adapts the EDF HTTP range-read and bipolar-pair method of this publication.