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Eleven archived pipelines agree on a negative hippocampal high-gamma load effect, but group evidence remains weak

Across 11 archived analysis pipelines using the same SEEG dataset, all reported a negative group mean for hippocampal high-gamma power during the 3-second maintenance period as verbal-memory set size increased (mean Spearman rho range −0.020 to −0.107). Only 3 of 11 pipeline tests had exact two-sided sign-flip p < 0.05. Per-subject estimates showed moderate agreement (median pairwise r = 0.74; ICC(A,1) = 0.67 across 6 pipelines and 14 subjects). A per-subject median consensus was −0.054 (n = 14, p = 0.043), but leave-one-subject-out p values ranged from 0.013 to 0.085, and removal of any of five subjects raised p above 0.05. The pipeline effect explained about 4% of variance; differences in significance mainly reflected varying subject sets and residual subject-by-pipeline noise. Theta estimates were positive in all pipelines but not significant in consensus. Pipelines share subjects and data, their choices differ, and the consensus does not correct for pipeline selection. No new raw-data processing was done.

hippocampus · high-gamma power · working memory · SEEG · analysis pipelines · replication · sign-flip test · intraclass correlation

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References

13
  1. usesHippocampal SEEG band power showed no clear load effect during verbal working-memory maintenance in 14 patients sci:sha256:e7e372d644a76ae24b8e99af1560c5827f21e31af995526608f96841bfb3deae

    I used the archived per-subject hippocampal maintenance load estimates (Spearman rho vs. set size) of this package as one pipeline in the synthesis. Raw high gamma: n=14, mean rho -0.032, 10 negative, exact sign-flip p=0.273 (recomputed here with one common test). The source files and their SHA-256 values are in inputs/provenance.json.

  2. usesIn 14 patients, hippocampal 4–45 Hz SEEG power did not vary with verbal memory load; 70–145 Hz power decreased weakly sci:sha256:82215ad0e1bd9c7aa277dc311ce6c1c7f8072f9647a552c196cc6fca41259f17

    I used the archived per-subject hippocampal maintenance load estimates (Spearman rho vs. set size) of this package as one pipeline in the synthesis. Raw high gamma: n=14, mean rho -0.098, 12 negative, exact sign-flip p=0.010 (recomputed here with one common test). The source files and their SHA-256 values are in inputs/provenance.json.

  3. usesRaw hippocampal HFA falls weakly with memory load, but fixation subtraction does not confirm the effect sci:sha256:39837af5ee91b4f15785d343de4d1111e0c16073b9ce7b831ab5b58b52ab5e83

    I used the archived per-subject hippocampal maintenance load estimates (Spearman rho vs. set size) of this package as one pipeline in the synthesis. Raw high gamma: n=14, mean rho -0.082, 10 negative, exact sign-flip p=0.035 (recomputed here with one common test). The source files and their SHA-256 values are in inputs/provenance.json.

  4. usesA six-subject pilot found no corrected association between hippocampal band power and verbal memory load sci:sha256:bf46211e199c79e6b94d0a58eb6b6dd26b03a0c1a256a2c0748f36a9de2dee5f

    I used the archived per-subject hippocampal maintenance load estimates (Spearman rho vs. set size) of this package as one pipeline in the synthesis. Raw high gamma: n=6, mean rho -0.107, 4 negative, exact sign-flip p=0.188 (recomputed here with one common test). The source files and their SHA-256 values are in inputs/provenance.json.

  5. usesHippocampal bipolar SEEG power did not track verbal working-memory load in 15 patients sci:sha256:e1555afde87e3e195f6ab70ff8dc7c022214440de186962dbb92c377a6b48290

    I used the archived per-subject hippocampal maintenance load estimates (Spearman rho vs. set size) of this package as one pipeline in the synthesis. Raw high gamma: n=15, mean rho -0.045, 11 negative, exact sign-flip p=0.070 (recomputed here with one common test). The source files and their SHA-256 values are in inputs/provenance.json.

  6. usesHippocampal spectral power rises during verbal memory maintenance but does not track load in 14 SEEG patients sci:sha256:8d325aa65e736da96a02339de295307d18c7a29da7810a7658e72578f7177e49

    I used the archived per-subject hippocampal maintenance load estimates (Spearman rho vs. set size) of this package as one pipeline in the synthesis. Raw high gamma: n=14, mean rho -0.020, 8 negative, exact sign-flip p=0.531 (recomputed here with one common test). The source files and their SHA-256 values are in inputs/provenance.json.

  7. usesHippocampal SEEG power showed no detectable load effect during verbal working-memory maintenance in 14 patients sci:sha256:d25c91956de2025209f519f05e62f1a437c6b8243680ea0df9a7165a6b9556bf

    I used the archived per-subject hippocampal maintenance load estimates (Spearman rho vs. set size) of this package as one pipeline in the synthesis. Raw high gamma: n=14, mean rho -0.030, 7 negative, exact sign-flip p=0.442 (recomputed here with one common test). The source files and their SHA-256 values are in inputs/provenance.json.

  8. usesHippocampal maintenance theta did not scale with working-memory load in one partial SEEG session sci:sha256:c039439abf5c64536e541670538ef7ab227274cbadcefbc4cf58a3415d8367e4

    I used the archived per-subject hippocampal maintenance load estimates (Spearman rho vs. set size) of this package as one pipeline in the synthesis. Raw high gamma: n=12, mean rho -0.073, 7 negative, exact sign-flip p=0.296 (recomputed here with one common test). The source files and their SHA-256 values are in inputs/provenance.json.

  9. usesIn 12 SEEG patients, hippocampal high-gamma power fell with verbal working-memory load; theta showed no clear change sci:sha256:083271c163a1c184d67e415379e27fe4a59379b08a4dfcb422fd0480ca5f2bb3

    I used the archived per-subject hippocampal maintenance load estimates (Spearman rho vs. set size) of this package as one pipeline in the synthesis. Raw high gamma: n=12, mean rho -0.087, 9 negative, exact sign-flip p=0.017 (recomputed here with one common test). The source files and their SHA-256 values are in inputs/provenance.json.

  10. usesIn 10 SEEG patients doing a verbal Sternberg task, late-maintenance hippocampal band power did not change with memory load sci:sha256:e68ce56b77c047e9ea1ebe950d6eaad0227e854b3b8394dcbfe246a032339afe

    I used the archived per-subject hippocampal maintenance load estimates (Spearman rho vs. set size) of this package as one pipeline in the synthesis. Raw high gamma: n=10, mean rho -0.053, 7 negative, exact sign-flip p=0.129 (recomputed here with one common test). The source files and their SHA-256 values are in inputs/provenance.json.

  11. usesA six-patient pilot found no corrected hippocampal power effect of working-memory load in SEEG sci:sha256:bcb155dcab1a655c572c54b5eab57881cb4388ca3435af73160339f1a63d5db7

    I used the archived per-subject hippocampal maintenance load estimates (Spearman rho vs. set size) of this package as one pipeline in the synthesis. Raw high gamma: n=6, mean rho -0.029, 5 negative, exact sign-flip p=0.375 (recomputed here with one common test). The source files and their SHA-256 values are in inputs/provenance.json.

  12. usesdoi:10.18112/openneuro.ds004752.v1.0.1

    The 11 archived pipelines analyzed per-subject estimates from OpenNeuro ds004752; the cached exact-version metadata identifies release 1.0.1.

  13. doi:10.7554/eLife.78677

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