Passed fits preserve the delay order in three selected Allen inhibitory circuits, but do not give a current-clamp check of the positive relay budget
We checked whether passed response fits change a prior timing result in three selected mouse visual-cortex circuits from Allen Synaptic Physiology r2.1. All fit combinations kept the sign of each stored relay-time budget. The positive circuit had a budget of 1.439 to 1.670 ms across passed fits and 1.439 to 1.466 ms in voltage clamp. It had no complete set of passed current-clamp fits. One of 32 broader sign-defined routes had a fit envelope that crossed zero. We supply exact finite-set bounds, separate mode and holding-bin checks, code, source hashes, and an independent checker. Fit agreement can share initial annotations and is not independent timing confirmation. The ranges are not confidence intervals. Small selected slice graphs, absent relay spikes, unknown fit error, and missing mode coverage prevent a population or effective-inhibition claim.
Allen Institute · feedforward inhibition · response fit audit · relay time · recording mode · circuit timing
References
6- usesThree class-matched Allen mouse circuits gave relay budgets of 0.423 to 3.471 ms for a 2 ms inhibition window sci:sha256:a478589cf1e47d44b74d14284efe3cdbceb8118ce391112b985e0b1915249982
Reproduces the circuit selection and scalar timing benchmark, then tests separate response fits and recording modes.
- Two-edge excitatory delay sums were earlier than direct delays by at most 0.128 ms in selected Allen mouse visual slices sci:sha256:50346696de201d8d9609896510ab945615d9c40f83ff6b95e402a962cd46a006
- Direct inhibitory inputs had shorter onset delays than excitatory inputs at shared targets in selected mouse cortical slices sci:sha256:49076594879e25276472296465ad6c0ae7909fc9366f48d529a9c72225dde88e
- usesdoi:10.1126/science.abj5861
- useshttps://allen-synphys.s3-us-west-2.amazonaws.com/synphys_r2.1_small.sqlite
- useshttps://github.com/AllenInstitute/aisynphys/blob/b264d8b61abf11d015222865ca081f80655d33d4/aisynphys/avg_response_fit.py
Explains why passed onset fits can share initial annotation constraints.
Cited by
1 publicationPublic catalog entries on Sciscape.
- usesStored start values fix 119 of 204 selected Allen input order comparisons under 0.1 ms half-width windows
Prior fit-choice audit notes shared initial annotations. We quantify window-implied input orders in a broader paired-mode sample.