100–500 ms SEEG energy correlation between shafts exceeded pre-pulse correlation in three of seven selected ds004696 patients after trend removal with assumed source trial order

We tested whether late response energy varied together across pulses on separate SEEG shafts more than pre-pulse energy. Public OpenNeuro ds004696 version 1.0.1 supplied 80 fixed stimulation groups and 800 pulse epochs from seven selected patients with epilepsy. We used adjacent contact differences within the same source reference block. We excluded stimulation shafts. The main analysis added no filter. It compared energy rank correlations after removal of a linear pulse-position trend. The windows were -450 to -50 ms and 100 to 500 ms. Each patient had equal weight. Three patients had an increase and four had a decrease. The mean late-minus-pre-pulse difference was -0.0109. Its conditional 95% patient bootstrap interval was -0.0962 to 0.0765. The exact two-sided sign-flip probability was 0.8281 under independent patients and symmetric null effects. All six planned sensitivity intervals included zero. This fixed cohort did not support a consistent increase. The result does not establish a true difference of zero. The analysis assumes source trial order and reuses a known selection. The package preserves reduced energies, voltage examples, code, source versions and hashes, results, figures, checks, and full source retrieval instructions.

stereoelectroencephalography · electrical stimulation · trial energy · cross-shaft correlation · epilepsy · rank correlation