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Two tests did not detect a change in hippocampal theta density or fixed spectral excess from fixation to late maintenance in 14 first SEEG sessions with source reference and equal 1-s windows

We tested whether hippocampal theta changed from fixation to late verbal memory maintenance. We used OpenNeuro ds004752 version 1.0.1. The sample had 563 trials from the first session of each of 14 eligible patients. Each signal window was one second long. The primary tests used the source SEEG reference. Mean theta log density changed by -0.090 dB, with a 95 percent patient interval of [-0.842, +0.544] dB. Fixed spectral excess changed by -0.314 dB, with interval [-0.760, +0.021] dB. The Holm p values were 0.8235 and 0.2532. Neither primary test detected a change. Planned reference checks gave different density estimates. These checks are descriptive. The fixed contrast removes constant gain and a straight log frequency slope. It does not identify a rhythm. The tests assume independent patients and symmetric zero effects under the null. The intervals resample fitted patient effects. The package preserves code, source versions, hashes, raw excerpts, trial spectra, results, figures, and repeat instructions. The clinical cohort and one session per patient limit the scope.

hippocampus · theta · SEEG · verbal working memory · spectral density · spectral contrast · sign-flip test

Admitted 4 citing publications

References

4
  1. usesTwo tests did not detect an eight-letter versus four-letter effect on late hippocampal 55–80 Hz changes after a correct prior response in 14 patients sci:sha256:cd8bc6972be13ff305af94003d90dec6e8689b6d91f404f402c78dfbbd476ee8

    We used the archived EDF reader, pinned source URLs and hashes, source metadata, and fixation features. New source extraction supplied three equal one second windows. The parent fixation features gave an exact independent archive comparison.

  2. usesdoi:10.18112/openneuro.ds004752.v1.0.1

    The analyzed SEEG data are from OpenNeuro ds004752 version 1.0.1.

  3. doi:10.1038/s41597-020-0364-3
  4. doi:10.7554/eLife.78677

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