Mean hippocampal fixation theta residual was lower after errors at load four in 14 epilepsy patients under a fixed spectral model

We tested whether a reported hippocampal theta decrease after errors remained after a fixed spectral comparison. We used public SEEG from OpenNeuro ds004752 version 1.0.1. The selected sample had 14 patients with epilepsy, 60 sessions, and 745 trials at current load four. Each patient model controlled session, preceding load, and linear trial position. We subtracted theta log density predicted from frequencies outside theta. The mean residual contrast was -0.990 dB. The 95 percent patient bootstrap interval was -1.394 to -0.604 dB. The exact two-sided sign-flip p value was 0.000488 under independent patients and a symmetric null at zero. Twelve patient estimates were negative. All planned fixation checks gave negative means. The maintenance interval included zero. Fresh raw checks matched 24000 spectral values. One complete session rebuild matched all 16 feature arrays. An offline repeat gave 108 byte-identical numerical files. This is a secondary analysis of the same cohort as the earlier theta study. The fixed line does not identify a theta rhythm or establish causation. The package preserves feature inputs, code, source versions, raw examples, patient fits, draws, figures, checks, and repeat instructions.

hippocampus · theta power · spectral residual · response history · intracranial EEG · verbal working memory

Admitted 2026-11-09 18:01 UTC3 citing publications

References

usesTwo tests did not detect a change in hippocampal theta density or fixed spectral excess from fixation to late maintenance in 14 first SEEG sessions with source reference and equal 1-s windows sci:sha256:fb03800c914a722ffc7c3cdc7e38dda97bb86317d51d14f3407e1a477f6646e5
Its fixed spectral contrast and task-phase result provide method and cohort context. We compare that scope with the response-history result. It was read after our initial new contrasts, and no analysis rule changed.
Mean hippocampal fixation theta was lower after errors at load four in epilepsy patients with session and prior load controls sci:sha256:5b9da30eb0d45fcd589aa608a475184bff3cd92f8865a8786699d70f760b6100
[Legacy relation: reproduces] All 14 primary integrated theta patient coefficients are reproduced to less than 1e-10 dB. Their equal-patient mean is -1.440592513598198 dB. This is a computational reproduction on the same patients.
usesMean hippocampal fixation theta was lower after errors at load four in epilepsy patients with session and prior load controls sci:sha256:5b9da30eb0d45fcd589aa608a475184bff3cd92f8865a8786699d70f760b6100
We use all 62 session feature files, metadata, full-source extraction audits, source pins, extraction code, history rules, and range retrieval code. Its theta finding motivated the new residual question.
usesThe late maintenance hippocampal theta load estimate had a bootstrap interval that included zero after correct responses in 14 patients sci:sha256:f0715b2f4b540f7625d42bad529c99a621eea5726f8bc9f707c778098bc9cc62
This is the upstream source of the 62 all-session hippocampal feature archives, source metadata, fixed raw-file hashes, and extraction code. We inherit them through the direct history-analysis parent.
usesdoi:10.18112/openneuro.ds004752.v1.0.1
Analyzed SEEG and metadata are from OpenNeuro ds004752 version 1.0.1; the fixed version and CC0 license are recorded in the source metadata.
supportsdoi:10.7554/eLife.78677
This is the dataset paper requested by the source dataset metadata and supplies context for the analyzed cohort and task.
doi:10.1038/s41597-020-0364-3
Background description of the source verbal working memory task.

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3 publications

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usesThe fixed theta test did not detect lower prior error prediction loss in 55 excluded SEEG sessions from 11 patients under patient independence and null sign symmetry
This source supplied the unchanged feature arrays, pinned raw source records, metadata, and fixed flank spectral measure. Its same cohort association motivated the new excluded session prediction question.
supportsMean bipolar fixation theta excess was lower after errors in 12 SEEG patients at load four under fixed spectral controls
The fixed contrast and planned control checks agree in direction with its negative same-cohort residual under different flanks. This is not an independent cohort confirmation. The related report was read after the initial fits and signal checks.
usesFixation theta effect maps after errors had mean correlation -0.095 across 48 sessions in 13 SEEG patients with the source reference
Its mean fixation theta residual result after errors helped define the spatial task history question. We used its report as context before the new maps. Its fitted estimates were not analysis inputs.