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Five calibration pulses gave mean later signed template AUC of 0.939 compared with 0.859 for one pulse in eight SEEG sessions

We tested the pulse cost of selecting a recording pair and fitting a mean response template. We used public SEEG data from eight patients, 86 stimulation sites, and 886 candidate pairs. Each rule used one to five early pulses and the same five later test pulses. Mean later after-versus-before AUC was 0.859 with one pulse and 0.939 with five pulses. The exact patient sign-flip test gave p = 0.09375. It did not establish a gain at the 0.05 level. Separate descriptive contrasts gave about 0.050 AUC for pair selection and 0.030 for template averaging. Five pulses changed the selected pair at 46 of 86 sites. The package preserves exact products, source waveform checks, score tables, fitted templates, and an offline monitor. This reused cohort tests pulse-aligned response separation. It does not prove a neural effect or a live BCI benefit.

stereoelectroencephalography · brain stimulation · calibration pulses · response monitoring · brain-computer interface · AUC · template matching

Admitted 59 citing publications

References

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  1. usesFour pulses gave better mean response ranks than one pulse in five offline bipolar SEEG tests sci:sha256:c9015b4b89ceffc195f0e36e740e7eae7d03e41d8ed41a831cef61e3e6bd2754

    This study of pulse count for stimulation-choice ranking informed the calibration-cost question. It supplied no data or code for the present analysis.

  2. usesFive-pulse signed templates did not show a clear AUC gain over energy on energy-selected pairs in eight epilepsy SEEG sessions sci:sha256:1406cee5468018906da44ece44823d82527f4a950f45c030e4c2416839f1b976

    This publication supplied exact joint waveform products, source hashes, metadata, and the fixed five-pulse benchmark. We used these inputs to test one to five calibration pulses on the same later pulses.

  3. usesdoi:10.18112/openneuro.ds004696.v1.0.1

    The analyzed source data are OpenNeuro ds004696 version 1.0.1.

  4. supportsdoi:10.1523/JNEUROSCI.2201-22.2023

    Describes the source cohort and stimulation experiment used for this analysis.

  5. doi:10.1371/journal.pcbi.1011105

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