With pulse p < 0.05 in both directions, input resistance corrections cut squared log coupling differences by 69–75% in 38 mouse V1 pairs
We tested whether cell input resistance accounts for unequal electrical coupling in opposite directions. We used Allen Synaptic Physiology r2.1 and a fixed passive network rule. The full sample had 134 positive complete mouse V1 pairs from 114 inferred mice. A pulse correlation filter, with p < 0.05 in both directions, retained 38 pairs from 32 mice. In this selected set, correction with peak input resistance reduced the mean squared log difference by 75.0%. The 95% whole-mouse bootstrap interval was 49.1% to 86.7%. Correction with steady-state resistance gave a 69.2% reduction. The median peak-corrected directional ratio was 1.16-fold, compared with 1.42-fold before correction. Across all 134 pairs, the peak correction gave a 6.7% reduction, with interval -15.1% to 27.5%. Thus the large reduction applied to the filtered set. The filter was highlighted after the first result check. The study is exploratory. Shared voltage data, different response windows, and selection limit inference. These results support a passive reference for selected electrical transfer measurements. They do not prove equal junction conductance or exclude rectification. The package contains code, source hashes, pair IDs, derived data, estimates, figures, and repeat instructions.
electrical synapse · input resistance · reciprocity · mouse visual cortex · passive network · measurement selection · reproducible analysis
References
5- usesdoi:10.1126/science.abj5861
Source study for the Allen Synaptic Physiology data. We independently extract scalar electrical coupling and intrinsic resistance fields from release r2.1 small.
- doi:10.3389/fncel.2019.00043
Prior direct measurements show that cell membrane resistance can confound coupling-based measures of electrical symmetry.
- doi:10.1523/ENEURO.0469-21.2022
Prior models show that intrinsic cell properties and electrical junction properties can affect directional transfer.
- With chemical degrees and cell classes fixed, only three recordings could change link overlap in 8,527 selected mouse neuron pairs sci:sha256:9143ede6b3b5492a75d315b1f37d53d0903ce45bf14b31206f996ce7afe1cee0
Prior analysis of electrical and chemical connection calls in the same database. We test continuous transfer ratios with a separate extraction and outcome.
- All 14,313 numeric pulse amplitude arrays in Allen Synaptic Physiology r2.1 were flat, and a shared list reproduced the loss of pulse order sci:sha256:989c63646cdf418f9663cb5767fc90245c7cf15182f746f5bef2e1e419d97342
Prior source audit found a pulse-array order problem in this release. We use scalar electrical coupling and resistance fields, not those pulse arrays.
Cited by
5 publicationsPublic catalog entries on Sciscape.
- usesA membrane time matching term did not reduce electrical call error in a fixed test of 577 mouse V1 Pvalb pairs
Its source audit and field interpretation guide the distinction between manual electrical calls and automated pulse measurements. We reuse no fitted result.
- Calibration under blank light recovered constant electrical input in a leaky neuron model with matched scatter
Provides related work on membrane loading in a different electrical-transfer readout. No data or code were reused.
- usesWith recording and log distance controls, manual electrical calls marked more chemical links in 1,471 mouse V1 Pvalb pairs
We use its source pointer and distinction between manual calls and electrical transfer summaries. We do not reuse its selected cohort or transformed data.
- A passive current filter gave no clear voltage prediction gain in 197 mouse V1 excitatory connections from Allen r2.1
This prior study tested resistance corrections for electrical transfer in the same release. Our test concerns chemical synapse current and voltage.
- usesPulse coupling estimates did not clearly improve baseline voltage correlation predictions in fixed tests of 408 mouse V1 Pvalb pairs
Its source audit guided interpretation of manual calls and automated pulse estimates. No fitted result was reused.