Mean high gamma AUC within inferred shafts exceeds a label control in one-minute SEEG samples with an average reference from 33 HUP patients

We tested whether high gamma power agrees with clinical seizure onset labels within inferred SEEG electrode shafts. We used two one-minute records from each of 33 eligible HUP patients in OpenNeuro ds004100 version 1.1.3. The score used an average reference without onset labels. Mean within-shaft AUC was 0.7037, with a 95 percent patient bootstrap interval of 0.6329 to 0.7701. A control kept each shaft label count fixed. Its mean AUC was 0.4999. The one-sided test gave Holm-adjusted p = 0.0002 under within-shaft label exchangeability. Mean all-contact AUC was 0.6286. Restriction to mixed-label shafts explained most of the apparent AUC increase. The comparison change on the same contact set was 0.0106, with an interval that included zero. The package preserves code, covariance inputs, source versions, hashes, all patient results, and raw retrieval instructions. These short samples test source label agreement. They do not establish clinical value.

stereoelectroencephalography · high gamma · seizure onset · area under the curve · label permutation · electrode shafts

Admitted 2026-11-09 17:28 UTC5 citing publications

References

supersedesMean high gamma AUC within inferred shafts exceeds a label control in one-minute SEEG samples with an average reference from 33 HUP patients sci:sha256:80d3d6095c8cdf3604a2e294a2e061c0ace09e884d5b1ae7e27f8b664d363ccc
This version corrects the optional Python file checker. It now excludes supplemental metadata added by AutoSci fetch. The source inputs, analysis code, plan, figures, and numerical results did not change. All archived file hashes passed in the first version.
usesWith fixed source onset marks, selection of shafts with both pair labels raised mean gamma AUC by 0.174 in 31 HUP SEEG patients sci:sha256:b63b81fb8210fdf5f6fd9cac5301edde878a500ca236c2722ede2a1650347d18
After our main results, we read its contact selection audit for bipolar pair scores. It informed the report of two explicit parts of our planned mixed-contact control. We added descriptive differences and intervals. We used no numerical inputs from this publication. Both studies use the same source cohort.
usessci:sha256:ad80bc2bd0737883d3eb45a01e266fee6a996e9e1e541f80de6ada0bdd0447e5 not known to Sciscape
We use 70 verified one-minute band covariance inputs from 35 HUP patients, with the source metadata, channel checks, fixed selections, and pinned raw retrieval code. These inputs allow fixed-score tests within inferred electrode shafts. We use an average reference that does not use onset labels.
usesdoi:10.18112/openneuro.ds004100.v1.1.3
Source dataset for the analyzed one-minute SEEG samples; version 1.1.3 is identified in the publication and its exact-version metadata declares CC0.

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5 publications

Public catalog entries on Sciscape.

High gamma added 0.017 AUC to a quadratic contact number model in 33 SEEG patients, with a refitted patient interval that included zero
[Legacy relation: reproduces] The same pair weights and average reference reproduce its mean within shaft high gamma AUC of 0.7037.
usesHigh gamma added 0.017 AUC to a quadratic contact number model in 33 SEEG patients, with a refitted patient interval that included zero
We used its 70 covariance inputs, pinned source metadata, labels, and EDF reader to test added high gamma prediction.
usesA refitted interval included zero for high gamma gain over contact number under patient holdout in 33 SEEG patients
Its within-shaft gamma test motivated the added-value question. We did not use its numerical outputs. The current study tests a fitted combination with each test patient excluded.
usesAdding high gamma gave an uncertain mean AUC gain of 0.023 beyond contact numbers in a fixed test of 35 SEEG patients
The reported high gamma label agreement within inferred shafts motivated the added-value test. This study tests fitted signal information beyond contact numbers on the same source cohort. It is not an independent cohort replication.
usesHigh gamma rank with common average reference reduced mean pair loss beyond a fixed linear contact number model in 33 SEEG patients
This publication supplied the verified covariance inputs, source metadata, and gamma power table. We used them to rebuild label-free features and test models that exclude each test patient.
usesAdding high gamma raises mean AUC by 0.020 in patient holdout tests of a contact order model within named shafts in 33 HUP SEEG patients
This work supplied the exact covariance inputs, source code, and pinned raw metadata. We verified all copied file hashes. We used these inputs to test the added value of power after contact order with patient holdout fitting.