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q-bio.NC · Neurons and Cognition

A linear inhibitory rule for starburst contacts gave no clear added axis tuning prediction in 269 ganglion cells from one mouse retina

We tested if starburst contact angles predict the motion axis response of retinal ganglion cells beyond published cell type. We used matched anatomy and calcium recordings from the e2198 mouse retina. The primary panel had 269 cells in 35 types outside eight known direction selective types. A linear inhibitory model used the second angular contact moment, one shared nonnegative gain, and type means. With one cell left out, the contact term increased squared response moment error by 0.31%. The 95% type resampling range for error reduction was -0.69% to +0.04%. Within-type phase alignment was 0.026; a conditional cell shuffle test gave p = 0.298. First angular moments gave median direction errors of 12.4 degrees in 27 On-Off direction selective cells and 24.1 degrees in seven On cells. The axis response repeated across stimulus repeats, with within-type alignment of 0.514. All planned alternate definitions gave no improvement for the constrained rule. These results limit a fixed contact-to-response rule in one retinal patch. They do not exclude other axis circuits. Contacts are not confirmed synapses, and fixed stimulus order can create repeatable bias. We preserve code, source hashes, derived data, predictions, and figures.

retina · connectome · structure and function · starburst amacrine cell · motion axis · angular moment · negative result · reproducible analysis

Admitted 2 citing publications

References

7
  1. usesdoi:10.1038/nature09818

    The source study supplied matched retinal anatomy and calcium recordings and established selective starburst wiring.

  2. usesdoi:10.1016/j.cell.2018.04.040

    We use its released contact profiles, cell matches, types, processed calcium traces, and coordinate conventions.

  3. usesIn one mouse retina, starburst contact direction predicted preferred motion direction within a median 12° for 26 On-Off and 23° for 7 transient On DS ganglion cells; arbor direction did not sci:sha256:d70a5a6322e8ec3db5b80f3d7871b4207590d3517332401bc14f8d9baeda0dc2

    We use its file format information and compare our first-moment controls with its direction results.

  4. usesLocal contact correction reduced motion prediction error in 27 cells from one mouse retina sci:sha256:be8277b484073d3a865b5e829d4dd0c2c24aaeedc71969d419baf8647372c367

    We use its record of the published angle transform and opportunity correction. We test a different angular order.

  5. With cell types excluded from training, directional contact fractions gave an uncertain 18% motion tuning error reduction in 302 ganglion cells from one mouse retina sci:sha256:68bca6ee92aa35b528db8802c021db39fc418600ab6fd314d7ac087c407f0a08

    Our second-moment test adds a separate limit on simple contact-based prediction. It does not retest its first-moment type-transfer result.

  6. doi:10.1523/JNEUROSCI.4554-15.2016

    This study measured orientation selective excitation and inhibition in mouse ganglion cells.

  7. doi:10.1016/j.celrep.2023.112030

    This study identified orientation signals in bipolar terminals and postsynaptic ganglion cells.

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